Posts tagged with "medicinal"

Szemui ho, 360 MAGAZINE, relaxation, cbd, vacation, holiday, paradise, calm

Which CBD Product Is the Best? 

Cannabidiol (or CBD for short) oil is derived from the cannabis plant. Although CBD is from cannabis, it does not get you high. It does have many therapeutic benefits and can be used to ease the symptoms of conditions such as anxiety. Different people have different responses to CBD oil, so it’s essential to try the oil for yourself to see what positive or negative effects you get. The following guide gives you some options to consider to choose the best CBD product for you.

What Are the Most Common CBD Products?

The CBD industry is growing by leaps and bounds. There are many preparations and products on the market, but CBD oil taken sublingually is one of the most popular CBD products. Vaping CBD is another common CBD product with its popularity growing as CBD becomes more mainstream. CBD products for animals are also becoming quite common. 

Aspects That Determine the Efficiency of a Product

The CBD industry is almost entirely unregulated to date. So it’s up to the consumer to ascertain what they are buying and using. Dosage amounts that are too low will not achieve the ‘optimum’ level for an individual, and they may subsequently feel no effect at all. Finding the correct dose of CBD to achieve your optimum results can take trial-and-error. Most proponents recommend starting with lower dosages and increasing the dosage if needed. 

You can find a range of concentrations available, from 100 mg up to 3,500 mg, which are recommended for a dosage of between .5 ml and 1.0 mil under the tongue. You may find that it’s easier to get a controlled dosage with edibles like gummies or capsules than with oil, which is delivered by a dropper. Users also find that more product is delivered by ingesting than via vaping.

Sublingual Consumption

There is a vein under the tongue called the sublingual gland. When a substance is administered under the tongue to the sublingual glands, it gets absorbed directly into the bloodstream, which is referred to as sublingual consumption or sublingual administration. Common sublingual consumption methods include CBD tinctures, CBD lozenges, and CBD sprays.

Bioavailability

Bioavailability refers to the proportion of a substance that enters the circulation when introduced into the body and thus will have an active effect. It’s basically the rate at which a substance is absorbed into the bloodstream. Bioavailability is an essential measurement tool since it determines the correct dosage administration of a substance. Sublingual CBD products generally have high bioavailability. 

Duration of Effect

It typically takes 15–30 minutes to feel the effects of a CBD tincture, and the effects are known to last between 4–6 hours, though it is partially a factor of how potent a dose is taken. 

Ingested CBD, either using edibles or capsules, takes a bit longer to have an effect, but the results will also last longer, compared to other methods of taking CBD. This is because when CBD products are ingested, it takes a while for them to be digested and then processed by the liver before making it to the bloodstream. Once they are in the bloodstream, you can start to feel their effects.

Convenience

Finding a CBD oil product that is convenient for you to use will determine its effectiveness. You needn’t make a trek to the store to buy CBD oil, as there are a plethora of online retailers with all the products at your fingertips. 

CBD edibles are one of the most convenient ways to use CBD oil, as you don’t need to worry about a cream, which requires time to apply, or vaping, which requires equipment. CBD capsules are often considered the most convenient, but CBD gummies are increasingly popular and very convenient. 

The market is so large that there are now CBD products for any indulgence, including CBD-infused soaps, bath salts, lip balm, eye cream, and other ways to take part in CBD’s benefits according to your fancy. Note that some products available in one state or country are not guaranteed to be available in the next.

Cost

According to HuffPost, price is often a marker of purity. They advise that if you see a CBD oil that claims to have a 100-milligram potency for less than $40, it’s likely that the CBD is not pure.  According to another source, a 1-ounce, or 30-milliliter, bottle of CBD oil may cost anywhere from $30 to over $200. What makes the discrepancy? Well, the potency of a bottle can greatly affect the price, as well as where it is manufactured. When trying to decide if a CBD product is priced right, you can ask the following questions: 

  • Is it grown organically
  • Is it grown domestically? 
  • What are the product reviews?

You can look for certificates of analysis (COA), which have to be issued by a licensed laboratory, which tests for potency and safety. This certification is pricey for companies and may add to your cost.

Method of Consumption

To complicate matters, there is a wide range of methods to experience CBD oil. You can ingest sublingually (as in various terpenes) or use edibles such as capsules, gummies, syrups or CBD infused coffee or tea. You can deliver CBD products via inhalation with vaporizers, smokeables, or topicals on the skin. Topicals vary, too. You can select CBD topical cream or sprays. The effects of each method differ from one individual to individual. 

Conclusion

The best CBD product is the one that suits you for cost, convenience, and outcome. Remember that you can expect very different results, depending on dosing, the condition that needs treating.

Vaughn Lowery, 360 MAGAZINE

4 reasons CBD is amazing for your health

CBD is now available across America in a whole variety of forms, including oils, gummies, and even body creams, all promising amazing therapeutic effects that pharmaceutical drugs simply cannot offer. Millions now take the hemp product on a daily basis, thanks to its ability to completely change how the user is feeling both on the inside and the outside.

Here are 4 reasons why CBD is amazing for your health.

Helps soothe anxiety

Around 40 million adults across the US are affected by anxiety disorders which leave them stressed and on edge for large portions of the day. While around one in six takes pharmaceutical drugs to help them through bouts of anxiety, it can cost over $80 a month and sometimes shows to be little or no help.

CBD has now shown to be a great treatment for mental health disorders, helping the body to produce more of its own natural cannabinoids and dopamine to relax the mind. This can also help patients to sleep better at night, too, which in turn works as a mood-booster.

Relieves pain

According to CBD Kyro, patients report pain as one of their top reasons for taking CBD. Cannabidiol is full of anti-inflammatory properties which help to reduce discomfort throughout the body and relax the user, making everything from muscle aches to chronic pain easier to deal with.

A large proportion of patients take CBD for arthritis, as it is known to reduce the frequency and intensity of their pain. Although it is yet to be approved by the FDA, one of CBD’s best uses is its ability to relieve muscle and joint aches.

Treats epilepsy

Following extensive clinical research trials, the FDA approved CBD oil medication Epidiolex for the treatment of seizures associated with two rare and severe forms of epilepsy back in 2018.

It followed the case of Charlotte Figi, a young girl from Colorado who suffered from Dravet Syndrome. Within a matter of weeks of taking CBD, Charlotte went from having up to 300 seizures a week to just two a month. The FDA had no choice but to take notice. Epidiolex was the first drug approved to treat Dravet syndrome.

Improves skin

While CBD is great for helping with health problems on the inside, it has also taken over the cosmetic world, too. CBD contains anti-oxidant properties which can lessen the appearance of wrinkles and help to keep the skin hydrated. Its anti-inflammatory properties discussed earlier step in to help with acne, too, reducing breakouts and redness by calming the skin.

CBD can also work to decrease the overproduction of sebum- a type of oil that is responsible for causing breakouts to appear on the face and neck. Daily CBD Mag also adds that CBD oil can also improve the strength and appearance of hair and nails.

Note

Unlike cannabis, CBD does not contain the chemical THC which is responsible for causing psychoactive effects. This is why it is generally considered safe for most people and even animals. When looking for a suitable CBD product, make sure it contains no more than 0.3% THC. 

CBD Buying Guide – How To Find The Best CBD Oil

In the medical industry, CBD oil has been the talk of the town as of late. It has shown to be an effective treatment for all sorts of conditions – from opioid addiction, depression and anxiety to muscle pains as well as epilepsy-related seizures.

Yet, this seemingly wonderous cure is not exactly “plug and play.” There are different ways of extracting CBD oil from marijuana plants, and many oil types out there, each carrying unique properties of their own. This means you will have to do some research to find the best CBD oil for your needs.

The first thing you should do before buying is to check your state laws regarding the legality of the products on offer. Some states allow for prescription-based CBD oil with under 0.3% THC concentration, whereas certain places allow for over the counter purchase of CBD products containing high amounts of THC.

There are three categories of CBD products on the market: Full Spectrum, Broad Spectrum and CBD Isolate.

Full Spectrum

CBD oil is only one ingredient that can be sourced from any given hemp plant. There are dozens of chemical compounds of the marijuana plant, which can prove more effective when taken in combination with one another – also known as the entourage effect.

Full Spectrum CBD refers to products containing a broad range of cannabinoids and terpenes present in the hemp plant. As such, they provide the most potent effect in treating your medical condition.

The downside, for some, maybe the fact that trace amounts of THC are present in full-spectrum products. While they are often in low amounts, not nearly enough to get you “high,” consistent use may get you flagged on drug tests. What’s more, some states make the sale of THC-infused oil flat out illegal or may require a prescription from a licensed physician.

Broad Spectrum

New strides in CBD processing technology have paved the way for high-quality oil extracts with no trace amounts of THC, classified as Broad-Spectrum CBD Oil.

Broad-spectrum oils still contain all the useful terpenes and cannabinoids present in the hemp plant, mirroring full-spectrum products. Through additional post-processing, all traces of THC are removed from the oil.

Therefore, it’s recommended that you consume broad spectrum oils if you do not want to consume THC for whichever reason.  

CBD Isolate

Before the production of broad-spectrum CBD oils was not yet possible, CBD isolates were the solution for individuals who couldn’t consume trace amounts of THC in their product.

The process for creating CBD isolates removes all terpenes and cannabinoids previously found on the hemp plant. The end result is 99%+ pure cannabidiol product.

However, since all other useful compounds from the plant are removed in the process, CBD isolates are much less effective as a treatment for relevant medical conditions. As such, your best choice for THC-free oil is broad-spectrum, rather than CBD isolates, if you can get your hands on one. 

Hanna Brand, Autumn Shelton, 360 MAGAZINE, Autumn Brands

Empowering Women Everywhere

Highlighting these Soaring Entrepreneurs on Women’s Equality Day

On August 26th,1920, the United States passed the 19th Amendment, which granted women the right to vote. Creating a much needed day to celebrate how far women fought to let their voice be heard.
We’ve come a long way, the rise of women, the laws we’ve overcome for women to make a stand, to the freedom we’ve secured in a society to become owners and trailblazers for today’s controversial passed laws — one being Cannabis. 

With heads standing tall, Autumn Shelton (Owner/ CFO) and Hanna Brand (Owner/ Sales Director) of Santa Barbara-based Autumn Brands are changing the culture and conversation around the female use of cannabis. The first to receive a California Provisional Annual Cultivation license in Santa Barbara County, Autumn Brands is a family-run, 50% woman-owned company known for its holistic focus and artisanal approach to producing powerfully potent strains of pesticide-free cannabis. From day one to the present, the company has sought to shift the female perspective, stigmas, and misunderstandings associated with the use of cannabis as part of a whole and healthy lifestyle. The extraordinary women behind Autumn Brands bring an uncompromising work ethic to the task of producing hand-selected, sun-grown buds which are hang-dried, hand-trimmed and cured to preserve maximum potency and full healing benefits. Determined to make their mark on a male-dominated cannabis industry, the company aims to serve a growing female health and wellness market eager to embrace the myriad benefits of cannabis as part of a healthy lifestyle.

Women’s Equality Day is more than just a day to celebrate our achievements, it’s also gives us a chance to empowering and uplift our fellow women! 

Let’s highlight these soaring women who are making an impact and are standing for something they believe in.

About Autumn Brands:

Autumn Brands is a licensed California cannabis cultivator dedicated to the synergy of health and wellness. The Autumn Brands’ family farm started in Holland more than a century ago, and today, sixth-generation farmers apply the same expertise garnered in growing the world’s finest tulips to producing pure and potent strains of cannabis in sunny, coastal Santa Barbara County. Autumn Brands is proud to be 50 percent woman-owned, free of pesticides and other harmful chemicals. For more information, visit www.autumnbrands.com

CBDistillery

CBDistillery was founded in 2015 by two Colorado natives. The legacy brand of Balanced Health Botanicals (BHB), CBDistillery was born with the mission to bring the highest quality, fairly priced CBD to the masses. CBDistillery is now one of the nations’ largest and fastest growing retailers of hemp-derived CBD products in the world, reporting $41.3 million for 2018 (450% growth YoY). Today, BHB owns and operated some of the largest manufacturing operations and brands, including CBDistillery, in the hemp-derived CBD market. Through vertical integration, BHB is uniquely positioned to control the entire process from seed-to-sale. BHB is known for its high-quality consumer-focused products and best-in-class manufacturing processes.

In a recent segment, co-hosts and lifestyle expert Lifestyle expert, Milly Almodovar gave viewers a breakdown of CBD and the different products available in the market.

Parkinsons and Medical Marijuana

Parkinson’s Foundation Hosts Its First-Ever Medical Marijuana and Parkinson’s Disease Conference

The Parkinson’s Foundation will host its first-ever conference focused on medical marijuana and Parkinson’s disease (PD) in Denver, CO, March 6-7, 2019.

The Parkinson’s Foundation is bringing together experts from across the globe to discuss the implications and recommendations of medical marijuana use for people with Parkinson’s,” said James Beck, PhD, chief scientific officer of the Parkinson’s Foundation. “Now that medical marijuana is legal in 31 states and in many other countries, people are equating access to efficacy. It is imperative that we address the clinical implications of medical marijuana use among people with PD.”

The goal of the conference is to bring together a diverse group of experts from academia, clinics, industry, government and the Parkinson’s community to establish a consensus on medical marijuana use in PD. The conference will address the potential benefits and risks of medical marijuana for people with PD, potential delivery methods, safety considerations, approval as a therapeutic for PD patients, and areas for more rigorous clinical research.

“Having worked as a clinician for the past decade in Colorado, a state at the forefront of medical marijuana use, it is clear that people with PD and their families are intensely interested in the potential of marijuana and cannabinoids in helping manage symptoms and other aspects of their disease,” said Benzi Kluger, MD, MS, associate professor of University of Colorado Hospital and co-chair of the conference. “To date, there is more hype than actual data to provide meaningful clinical information to patients with PD. There is a critical need to analyze existing data on medical marijuana and to set priorities for future research.” Moreover, some people are so convinced of the effects of cannabis on people with PD that they go as far as growing the seeds themselves as it’s proven cheaper than buying it from medical dispensaries. You can use this link to find out more about online seedbanks that ship to the USA if you’re interested in that.

Recent results from a survey conducted by the Parkinson’s Foundation and Northwestern University, a Parkinson’s Foundation Center of Excellence, found that:

    • 80% of patients with PD have used cannabis
    • 23% of doctors received formal education on medical marijuana
  • 95% of neurologists have been asked to prescribe medical marijuana

People with PD and their physicians are looking to answer whether medical marijuana can help manage PD symptoms. Few clinical studies have enrolled people with PD to investigate the effects of medical marijuana on PD symptoms. There is currently no conclusive scientific research supporting the benefits of medical marijuana for PD, however, anecdotal evidence suggests that it may help manage Parkinson’s symptoms such as pain, sleep, appetite, nausea and anxiety.

“In order to move the field forward, we need to determine which cannabinoids are likely to be beneficial or harmful, whether people with PD are at risk from side effects, what we are hoping to treat, and how to conduct informative clinical trials,” said A. Jon Stoessl, MD, co-director of the Djavad Mowafaghian Centre for Brain Health at the University of British Columbia, and co-chair of the conference.

The conference is invitation-only. In addition to Parkinson’s specialists, select Parkinson’s advocates living with PD will be invited to provide their perspective. The Foundation will publish suggested practices and areas for further research following the conference.

For more information on medical marijuana and PD, call our Helpline, 1-800-4PD-INFO (473-4636) or visit Parkinson.org/Marijuana.

About the Parkinson’s Foundation
The Parkinson’s Foundation makes life better for people with Parkinson’s disease by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson’s community. For more information, visit www.parkinson.org or call (800) 4PD-INFO (473-4636).

About Parkinson’s Disease
Affecting nearly one million Americans and 10 million worldwide, Parkinson’s disease is the second-most common neurodegenerative disease after Alzheimer’s and is the 14th-leading cause of death in the United States. It is associated with a progressive loss of motor control (e.g., shaking or tremor at rest and lack of facial expression), as well as non-motor symptoms (e.g., depression and anxiety). There is no cure for Parkinson’s and 60,000 new cases are diagnosed each year in the United States alone.

Endothelial progenitor cells for treating stroke patients

A new study recently published in STEM CELLS Translational Medicine demonstrates the long-term safety of laboratory-expanded endothelial progenitor cells for treating ischemic stroke. This could be good news for the 15 million people who, according to to the World Stroke Organization, suffer from this dangerous condition each year.

Ischemic stroke is the most common type of stroke, affecting nearly 90 percent of all cases. It is caused by a blocked blood vessel in the brain. In the normal central nervous system, endothelial progenitor cells (EPCs) play an active role in building blood vessels. This has led researchers to wonder whether EPCs circulating in the blood could be recruited after a stroke to assist in repairing damaged vessels in the brain. However, there is one major problem with this idea: The number of circulating EPCs is too low to provide much regenerative capacity – a number that further decreases in the aging or in those with heart problems.

This makes ex vivo (lab) expanded EPCs an attractive alternative.

“Transplantation of EPCs was already determined in animal experiments to be a safe and effective method for treating ischemic stroke. However, their safety and efficacy had yet to be determined in humans,” said Zhenzhou Chen, M.D., Ph.D., Southern Medical University, Guangzhou, China, and a corresponding author on the study. “In our trial, we tested the safety and feasibility of transplanting an acute ischemic stroke patient with his or her own (autologous) ex vivo expanded EPCs.”

Eighteen patients were recruited for the randomized, single-blinded study. Each received conventional treatment after their stroke then, seven days after symptom onset, underwent a bone marrow aspiration to collect EPCs and bone marrow stromal cells (BMSCs) for expansion in the lab. The patients were divided into three groups and, beginning at week four after the aspiration, one group was intravenously infused with their own EPCs, while the other two groups received either their own BMSCs or a saline placebo as the controls.

Each patient was then monitored for 48 months. Study co-author Xiaodan Jiang, M.D., Ph.D., also from Southern Medical University, explained, “We watched for mortality of any cause, adverse events and any new-onset diseases or conditions. Changes in neurological deficits were also assessed at different time points.”

In the end the researchers found no toxicity events nor did they see any infusional or allergic reactions in any of the patients. “The EPC group had less serious adverse events compared to the placebo-controlled group, although there were no statistical differences in mortality among the three groups,” Dr. Chen reported. “Ex vivoexpansion always raises concerns that it may cause instability in the chromosomes or maybe lead to tumors. However, in our long-term study we observed no increased tumorigenicity. This safety indicator was also confirmed by many animal studies and other trials using expanded bone marrow-derived stem cells for treatment of ischemic stroke.”

The researchers did note limitations in their study, including lack of patient-centered quality of life outcomes. “Moreover, because of the small size of the cohorts involved, we could neither identify the neurological or functional benefits of EPCs on ischemic stroke, nor determine the pros and cons between EPCs and BMSCs for stroke treatment,” Dr. Jiang said. “Thus, we believe a larger phase 2 trial is warranted.”

“This is a promising line of cell therapy research using a novel treatment method that is simple and non-invasive,” said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. “We look forward to larger phase 2 trial results.”

The full article, “Autologous endothelial progenitor cells transplantation for acute ischemic stroke: A four-year follow-up study,” can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices. SCTM is the official journal partner of Regenerative Medicine Foundation.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (www.StemCells.com), celebrating its 36th year, is the world’s first journal devoted to this fast paced field of research. The Oncologist® (www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 23rd year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

About Wiley: Wiley, a global company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical and scholarly journals, combined with our digital learning, assessment and certification solutions, help universities, learned societies, businesses, governments and individuals increase the academic and professional impact of their work. For more than 200 years, we have delivered consistent performance to our stakeholders. The company’s website can be accessed at www.wiley.com.

About Regenerative Medicine Foundation (RMF): The non-profit Regenerative Medicine Foundation fosters strategic collaborations to accelerate the development of regenerative medicine to improve health and deliver cures. RMF pursues its mission by producing its flagship World Stem Cell Summit, honouring leaders through the Stem Cell and Regenerative Medicine Action Awards, and promoting educational initiatives.