Posts tagged with "medication"

CBD: An Alternative to Prescription Drugs?

In the modern world, our first approach to treating an illness is to find the most suitable pharmaceutical drug, which we typically get either over-the-counter or on prescription. However, while these medicines are normally effective, they can unlock a whole new box of issues, including dependency and side effects.

Becoming reliant on medication can be mentally unsettling, and nasty side effects like nausea and dizziness typically require further treatment, leaving patients on a cocktail of pharmaceutical-grade drugs before they know it.

In the case of opioid painkillers, dependency may even be life-threatening, with the risk of overdose frighteningly high. In 2016, abuse of prescription opioid painkillers and recreational opiates accounted for more than 40,000 US lives, according to the Centers for Disease Control and Prevention (CDC).

This cycle of illness, drugs, side effects and more drugs is wearing thin with many, and combined with the new wave of medical cannabis science, a clear divide has formed between those who favor prescription drugs, and those who’d rather take natural, plant-based medicines.

From a historical perspective, medicinal cannabis use makes perfect sense, with the herb being used for millennia across the world, but particularly in Africa and Asia.

Technological advancements have greatly developed our knowledge of cannabis, and scientists now know which compounds are responsible for various effects. For example, the psychoactive “high” mostly comes from a therapeutic cannabinoid called tetrahydrocannabinol (THC). However, numerous other cannabinoids have medicinal properties, sans the hallucinogenic effects.

Cannabidiol (CBD) is the most studied and seemingly most useful non-intoxicating cannabinoid, and the market for CBD products has exploded in the 2010s, thanks in part to the relaxation of laws surrounding non-psychoactive hemp.

CBD over opioids
Opioid-based painkillers like Tramadol are now regularly prescribed for chronic pain, with stronger synthetic drugs such as fentanyl available on prescription for the most extreme discomfort. These drugs are designed to interact with opioid receptors in the opioid system. The pain relief from these drugs is substantial, however sustained use leads to increased tolerance, stronger doses and addiction.

However, CBD may be helpful for chronic patients, and also those who have ended up dependent on opioids, as the cannabinoid seems to exhibit anti-addiction properties by interfering with pleasure-reward mechanisms.

By elevating concentrations of anandamide in the body, CBD is promoting a neurotransmitter that works to ease both physical and mental pain. How CBD tackles addiction is less clear, but some evidence indicates that CBD is active in the opioid system.

Not all pain is the same – for example, some chronic pain is persistent and always at a similar intensity, whereas the worst effects of inflammatory and neuropathic pain tend to come from flare-ups.

For internal neuropathic pain, CBD vape oil and e-liquid treatment is ideal, because the relief comes very quickly. Meanwhile, lingering pain is economically and perhaps more efficiently managed by orally-consumed CBD products (e.g. capsules, edibles, coffee).

Experimenting with gels, creams and balms infused with cannabis or CBD is a novel method of coping with localized pain. These ensure that the cannabinoid receptors in the affected area are directly activated.

CBD: the new anti-inflammatory drug?
Immune system response is still not well that understood, and this has made it difficult to control. Researchers have struggled to find ways of influencing inflammation, but studies into the endocannabinoid system have found that immune system response is accessible via cannabinoid receptor 2 (CB2). Endocannabinoids look to signal a stoppage in inflammation, after a wound has fully healed or an infection is neutralized.

This discovery may be crucial, as the current leading class of anti-inflammatories (non-steroidal anti-inflammatory drugs, or NSAIDs) are known to cause concerning side effects, including stomach ulcers.

The best CBD product for inflammation depends, unsurprisingly on the type of inflammation. Internal conditions like irritable bowel syndrome (IBS), which could be exacerbated by endocannabinoid deficiency, respond well to both CBD vape juice and CBD edibles, or even tincture oils.

For osteoarthritis, a form of inflammation which affects the joints, CBD creams and other topicals are likely to produce better results.

CBD’s promise as an antidepressant
Cannabinoid research is providing genuine hope for antidepressant researchers, after decades of stagnation in medication development. The current situation with depression medicine is far from ideal, with selective serotonin reuptake inhibitors (SSRIs) slow to show benefits – for up to 40 percent of patients, these drugs may not even work at all. And then there are the side effects to contend with, which range from drowsiness to impotence. Depersonalization and derealization have also been anecdotally reported with SSRIs.

However, a glut of promising studies on CBD and the brain have found that the ECS could be important in correcting off-balance brain chemistry. The CB1 receptor modulates many variables, mood being one, and the bond between anandamide and this receptor is important for good mental wellbeing. Factors outside of the ECS also affect mood, but the potency of anandamide as an antidepressant makes the link with the CB1 receptor an essential one.

Some of the most exciting research on cannabinoids has been on their neuroprotective and neurogenesis properties. Studies on the hippocampus and the prefrontal cortex and cannabinoid treatments, which are associated with depression, have demonstrated that CBD is able to repair these regions of the brain, by restoring neuronal circuitry and helping to form new brain cells.

A 2018 study on rats carried out in Brazil showed that CBD was effective from the first treatment and for up to seven days after the last dose at blocking synaptic proteins which damage neuronal circuitry in the prefrontal cortex. Meanwhile, CBD-initiated neurogenesis in the hippocampus helps to regrow the brains of adult rats with depression. These results have not yet been replicated in humans, but rats are used for such studies because their brains are similar to humans. General memories and our autobiographical memory are stored in the hippocampus.

The only CBD products that aren’t suitable for managing depression are topicals, as the cannabinoids remain in the skin, and do not reach the brain.

YUNGBLUD SHARES VIDEO FOR “MEDICATION”

YUNGBLUD shares the video for “Medication,” the new single from his full-length debut, 21st Century Liability, available now on Locomotion/Geffen Records.  The video, directed by Adam Powell, (The 1975, Pale Waves)  can be viewed HERE.

YUNGBLUD (Dominic Harrison) says, “I think growing up in a heavily medicated, overprescribed society you quickly learn how to use drugs to distract yourself from addressing what’s going on in real life.”

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“Medication” eSingle

Retail: http://smarturl.it/MedicationYB

Amazon: http://smarturl.it/MedicationYB/amazonunlimited

Apple Music: http://smarturl.it/MedicationYB/applemusic

Google Play: http://smarturl.it/MedicationYB/googleplay

iTunes: http://smarturl.it/MedicationYB/itunes

Spotify: http://smarturl.it/MedicationYB/spotify

Tidal: http://smarturl.it/MedicationYB/tidal

Martha Stewart

Watch: https://youtu.be/dG_W9K–Hz0

Did you know that the daily pill that saves your life if you’re living with HIV costs just 20 cents a day in sub-Saharan Africa? Highlighting the impact that just 20¢ can have on someone’s life, the new EAT (RED) SAVE LIVES PSA, featuring Martha Stewart, Padma Lakshmi, Elizabeth Falkner, Hannah Bronfman, Angie Mar, Dana Cowin and Hong Thaimee, reminds food fans worldwide the power of what two dimes can buy when you choose to EAT (RED) this June.

(RED)’s fifth annual culinary campaign features an exciting line-up of chefs, food and drink activations, dining experiences and products to turn people’s food and drink choice into a force to fight AIDS, by raising money and awareness for the Global Fund. There are so many ways for food fans worldwide to get involved June…

  • Eat out at restaurants like Blaze Fast Fire’d Pizza where you can order the (RED) VINE Pizza at more than 260 of its locations across the U.S, donating $1 for every order of a (RED) Vine and a Coke, up to $50,000.

  • Order in from Jeni’s Splendid Ice Creams who will offer a special (RED) Collection for the month of June. Featuring five lovingly made flavors – Coffee with Cream & Sugar, Goat Cheese with Red Cherries, Ricotta Toast with Red Berry Geranium Jam, Ndali Estate Vanilla and dairy-free Dark Chocolate Truffle – delivered straight to your doorstep, each purchase will generate $6 to fight

  • Attend a PlaceInvaders series of intimate pop-up events in New York and Los Angeles. Hosted in secret residential properties, each brunch and dinner seating will feature menus by NYC- and LA-based chefs including Angie Mar (The Beatrice Inn), Patti Jackson (Delaware & Hudson), Sara Kramer and Sarah Hymanson (Kismet and Mad Capra), Jessica Koslow (Sqirl) andMei Lin (Nightshade). Tickets include five courses, (BELVEDERE)REDcocktails, and Josh Cellars wine, and are priced between $120-$150, with $18 from every ticket sold going to fight AIDS – enough to provide 90 days of life-saving medication.

Damian Marley x Living It Up

DAMIAN MARLEY “LIVING IT UP” VISUAL AVAILABLE NOW EXCLUSIVELY ON TIDAL

Today, Damian “Jr Gong” Marley premiered the music video for his impassioned single “Living It Up” off his GRAMMY Award-winning fourth studio album, Stony Hill, exclusively on global music and entertainment platform, TIDAL.

 

In the visual, Marley takes his son back to his hometown in Jamaica to share the culture of where his father Bob Marley grew up and where reggae music was born, as well as the parallel between his upbringing and where he is now.

 

The video was directed by Gil Green, and filmed in Trenchtown, Stony Hill and Port Antonio, Jamaica.

 

“If I have to pick a single track that represents the theme of the album overall, I would say it is probably Living It Up, it represents my history. It comes down to where my father is coming from and where my mother is coming from, it’s not likely that people from these two worlds meet up like that on a regular basis and have children. That whole journey, I think is an inspiring story in itself” says Marley about the track.

 

Previously, the TIDAL artist-owner collaborated with the platform to debut the visuals for “Speak Life,” “Stony Hill to Addis” DocumentaryTIDAL X: High Times, a 4/20 celebration. “Medication“, “Nail Pon Cross” as well as performed during TIDAL’s annual charity concert in 2016, TIDAL X: 1020.

 

 

TIDAL’s commitment to connecting fans with their favorite musicians has spanned dozens of livestreams, thousands of ticket giveaways, and an extensive array of exclusive content – including: TIDAL X Brooklyn, the annual star studded benefit concert; TIDAL X livestreams from Chance the Rapper, Ty Dolla $ign, Alicia Keys and more; exclusive album premieres such as Beyonce’s LEMONADE and Rihanna’s ANTI; unique content including 21 Savage’s 30 Days with 21 Savage, Rick Ross‘ album annotations and more!

 

WATCH ON : TIDAL.COM/DAMIANMARLEY

AMAZON × (RED)

·      Amazon joins (RED) in the fight to end AIDS with special holiday shopping experience and exclusive content on Amazon.com/RED

·      Special edition (RED) Echo launching today, Amazon will donate $10 to fight AIDS for every (RED) Echo sold

 

(RED) and Amazon are teaming-up for(SHOPATHON)RED – a special holiday shopping experience offering people a selection of exclusive (RED) products that raise money for the Global Fund to fight AIDS in Africa.

From November 20th through the end of December, shoppers can choose from more than 150 (RED) products including fashion, cosmetics, kitchen goods, tech and more at Amazon.com/RED or via the Amazon App. On December 1st, World AIDS Day, Amazon will highlight (RED), the Global Fund, and (RED) products to bring awareness to the fight, and throughout the campaign special video content from (RED) celebrity supporters will encourage people to shop (RED) and save lives this holiday season.

 

Sharing smart ways to shop and give back, stars including Neil Patrick Harris, Tyra Banks, DJ Khaled, Ricardo Kaka, Allison Williams, Javier Munoz, Jay Ellis, Yvonne Orji  and supermodel Anne V highlight their favorite (RED) product picks, available on Amazon.com/RED.

To underline the impact shoppers can have by choosing (RED) products this holiday, Allison Williams, Jay Ellis and Yvonne Orji came together with (RED) in Africa to visit (RED) supported programs on the ground. You can see and share this short video here.

As the Official Payment Provider of (SHOPATHON)RED, long-standing (RED) partner Bank of America is making every dollar spent go even further. For every dollar spent on Amazon.com/RED from November 20 until December 31, Bank of America will donate 30 cents – the daily cost of life-saving HIV/AIDS medication in sub-Saharan Africa – up to $1.5 million.

Among the selection of tech products is the brand new (RED) Amazon Echo. Amazon is donating $10 from the sale of each (RED) Echo to the Global Fund. Learn more about the new Amazon (RED) Echo here: www.amazon.com/redecho

Every (RED) purchase made by shoppers this holiday will have real impact. The life-saving ARV pills, when taken daily, save not only the life of mothers living with HIV; they also prevent the virus being passed to their unborn babies. As well as providing medication, (RED) money to the Global Fund also supports prevention, testing, counseling and care services programs – all key pillars of the fight to end a disease which is preventable and treatable; a disease which needlessly sees an adolescent become infected every two minutes.

Deborah Dugan, CEO, (RED), said: “Our collaboration with Amazon will make the gift of giving more impactful than ever before. I’m so grateful to the incredible team at Amazon who have made our ambitions of turning the holidays ‘(RED)’ a reality. Together with their enormous customer base, Amazon is helping to ensure lifesaving HIV/AIDS services are being delivered to communities most in need.”