Posts tagged with "Japan"

AUTUMN ART COLOURS × PARK HOTEL TOKYO

Autumn ART Colours Exhibition Scheduled at Park Hotel Tokyo to Offer Hospitality Guests a Season of Japanese Aesthetics

Park Hotel Tokyo announced on June 28 that it will hold an art exhibition titled “Daisuke Kagawa Art Exhibition – A Visitor from Afar in Autumn -” from September 2 to December 1, 2019.Park Hotel Tokyo welcomes our hospitality guests with the form of “arrangement”, one of Japan’s aesthetic values, expressed through the medium of art. A series of art exhibitions are held representing the four seasons of Japan. In this 30th exhibition as part of this initiative, “ART colours”, works of Daisuke Kagawa will be exhibited to express “autumn,” symbolising a condensation of the views of nature held by ancient people in Japan.

 

Twice a year, once each in spring and autumn, there is a period when the sun rises from true east and sets in true west. These seasons have long been familiar in Japan as the equinoctial weeks. During this time in autumn, people give thanks for the blessings of nature while venerating ancestors. It is a time for worshiping the sun, with prayers for the coming year’s harvest. The “Visitor from Afar” in the title is a term that refers to natural phenomena or things (i.e., the gods) that exceed human knowledge, coming from an eternal and faraway world. It is said that this became folk tradition, and that the people of Japan have welcomed visitors with reverence, cultivating methods of warm hospitality.

Daisuke Kagawa is an artist who draws on his own sensibilities and knowledge to create works that express the workings of “Visitor from Afar”. He drew attention with the production of an Artist Room called “Jomon” in the Park Hotel Tokyo’s Artist in Hotel project in 2017. The exhibition this autumn will deepen this Kagawa-style “Jomon” world. Here, “Visitors from Afar” await guests at the Park Hotel Tokyo.

During the exhibition period, guests can enjoy an original cocktail and dessert that complement artworks at the ART Lounge. In the evening, powerful images with a motif of exhibited artworks will be projected on the 30-meter-high wall.

 

Park Hotel Tokyo General Manager Takayuki Suzuki said:

“Autumn is also a time when we pray for a plentiful harvest after the scorching hot summer. I look forward to being able to meet with the blessings of Japan and feeling of gratitude that arrive with the golden light of autumn here in Tokyo.”

 

Park Hotel Tokyo Art Project Director Yoshitomo Fujikawa said:

“The work is modern, but it has an atmosphere that serves as a vivid reminder of ancient Japan. This exhibition likens the hotel to autumn through the work of artist Daisuke Kagawa, which enables one to catch a glimpse of Japanese identity.”

 

Enjoy a tranquil and rich autumn, with its balanced days of equal daytime and night, together with works of art that summon a deep-seated awareness of nature, at Park Hotel Tokyo.

THE WORLD’S 50 BEST RESTAURANTS

The World’s 50 Best Restaurants, sponsored by S.Pellegrino & Acqua Panna, announces the 51-120 list of restaurants ahead of its annual awards ceremony, which takes place in one week’s time on Tuesday, 25th June 2019 at Marina Bay Sands in Singapore. For 2019 only, the list expands from 51-100 to 51-120 restaurants, in celebration of the 120th anniversary of S.Pellegrino, partner of the gastronomy community since the beginning of its history in 1899. Deloitte, a professional services consultancy, is again independently adjudicating the list that is compiled by a diverse voting Academy which comprises over 1,000 international chefs, food writers and traveling gastronomes.

The 51-120 list in numbers – developing diversity

  • The 51-120 boasts 21 new entries from 15 countries, marking a near 30% increase in new territories this year
  • The full 51-120 list includes restaurants in 25 countries across five continents, with four new countries joining the list
  • There are six re-entries from four countries: Denmark, Japan, France and South Africa
  • It’s been a fine year for Italy with three first-time entrants
  • The highest new entry on the 51-120 list at No.61 is Uliassi in Senigallia, Italy
  • Nobelhart & Schmutzig in Berlin, Germany rises an impressive 31 places from last year to No.57, with
    Indian Accent in New Delhi, India following in close second, advancing 30 positions to No.60
  • USA leads in volume with seven restaurants on the 51-120 list, including one new entry
  • Japan and Spain are hot on the heels of USA with six restaurants each, including four new listings

Female Forward
There is a strong female presence this year, most notably with an exciting new entry from Core by Clare Smyth in London (No.66), the restaurant led by the winner of The World’s Best Female Chef Award 2018. Other female-led restaurants include Elena Arzak’s Arzak in San Sebastian, Spain (No.53), Pim Techamuanvivit’s Nahm in Bangkok, Thailand (No.69), Helena Rizzo’s Maní in São Paulo, Brazil (No.73),Garima Arora’s Gaa in Bangkok, Thailand (No.95) and Anne-Sophie Pic’s eponymous restaurant in Valence, France (No.98).

50/50 Split
As a result of the gender-balanced voting Academy announced in early 2019, more than 500 female experts, chefs, food writers and restaurateurs, make up 50% of the total voting Academy, establishing equal representation within the group of 1,000-plus international restaurant industry experts.

Widening the net
Some less celebrated gastronomic locations now appear on the 51-120 list, including the Marche region in Italy with Uliassi (No.61); southern Spain’s Aponiente (No.94) in El Puerto de Santa Maria; Guadalajara in Mexico with Alcalde (No.109); Ghent in Belgium with Chambre Séparée (No.111); and the Dolomites in Italy with St. Hubertus (No.116).

William Drew, Director of Content of The World’s 50 Best Restaurants, comments: “This year’s 51-120 listmarks the most expansive representation of geographic diversity we’ve seen during the 18 years that 50 Best has been celebrating culinary excellence. Restaurants from world-renowned countries as well as lesser-known destinations are voted for and will be acknowledged at The World’s 50 Best Restaurants awards in Singapore on 25th June. The advent of S.Pellegrino’s landmark anniversary marked the ideal opportunity for us to extend the list for one year only. We hope to see as many of them as possible again next year.”

In a collection of restaurants marked by their geographic spread, 21 new entries appear on this year’s 51-120 list of The World’s 50 Best Restaurants, marking a notable increase of represented countries and cities compared to previous years. There are three new entries apiece for Japan, Italy and China (including two from Hong Kong and one from Macau). Russia sees two new entries, both from St. Petersburg, challenging what has previously been Moscow’s domination. Lido 84 on Lake Garda, Italy (No.78) – this year’s winner of the Miele One To Watch Award – is another significant newcomer to the list, alongside Uliassi, which is the highest new entry in the 51-120 list.

Berlin’s Nobelhart & Schmutzig, last year’s No.88, has climbed the ranking an impressive 31 places to No.57, followed by Indian Accent in New Delhi, which advanced 30 places from last year to No.60.

SingleThread of Healdsburg, USA, last year’s Miele One To Watch winner, continues to demonstrate its predicted progress to No.71, jumping 21 places. Other notable climbers include Rio de Janeiro’s Lasai,bumping up 26 places to No.74, and Diverxo of Madrid landing at No.75 from No.96.
USA boasts an impressive seven restaurants on the 51-120 list, with Atomix, New York, debuting at No.119. Spain and Japan closely follow with six restaurants each, and Denmark, France, Germany, Italy and the UK are each represented by four restaurants.

The Voting Process
The World’s 50 Best Restaurants 2019 list is voted for by more than 1,000 international restaurant industry experts and well-travelled gourmets who make up The World’s 50 Best Restaurants Academy. The gender- balanced Academy comprises 26 separate regions around the world, each of which has 40 members including a chairperson. No sponsor from the event has any influence over the voting process. Professional services consultancy, Deloitte, independently adjudicates the World’s 50 Best Restaurants list. This adjudication ensures that the integrity and authenticity of the voting process and the resulting list of The World’s 50 Best Restaurants 2019 are protected.

Results
The best way to follow the announcement of the list and individual awards is via our social media channels:

Seiko USA, Lorem Ipsum, stevie award, 360 MAGAZINE

Lorem Ipsum Receives Gold Stevie® Award for Seiko USA Campaign

Multi-disciplinary experiential design firm, Lorem Ipsum is pleased to announce that its work for Seiko USA has received a Gold Stevie® Award from the American Business Awards® in the Website category under “Consumer Products-Non-Durables.”

The award was presented on Tuesday, June 11 during the 17th Annual American Business Awards banquet in New York City. The American Business Awards feature a wide selection of categories to recognize the achievements of creative professionals working in web development, corporate communications, video production, app development, investor relations and live events.

Lorem Ipsum took on the challenge of taking Japanese manufacturer of watches, Seiko USA’s website which was absent of sales or software integration capabilities, and built a sales-drivensite using Shopify’s platform. As storytellers in a digital world, Lorem Ipsum’s goal in both the user experience and overall design was to ensure the product remained the ultimate focus while keeping with the brand’s aesthetic and transforming Seiko enthusiasts into paying customers. Their approach not only provided significant technical enhancements but also told the brand story with new and improved user experiences across all devices. Lorem Ipsum’s team of programmers created the Seiko Sync app, expanding the native Shopify features to create aunique consumer experience. For example, customizable filters allow users the option to searchfor products by technology, dial color, size and various other important consumer factors.

Their developers also created custom software, such as Shop Social, that enables enhanced capabilities beyond Shopify’s existing offerings, including a unique Instagram plug-in that integrated directly with the brand’s channel allowing for a continuous and curated feed of imagery.

By moving away from traditional marketing approaches and instead, utilizing social media and strategic retargeting tactics, Lorem Ipsum was able to drive traffic to Seiko’s U.S. page and increase sell-through. The customer management process was also customized while working closely with Seiko’s IT and fulfillment teams to create a cohesive system of applications and notifications to give Seikobetter sales and product functionality insights; ultimately, allowing Seiko to better understand end-users’ likes and dislikes in order to create content accordingly to engage users and improvethe overall purchase process.

“It is an honor to be recognized for our contribution,” says Abigail Honor, Partner at Lorem Ipsum. “Working with Seiko to launch their first U.S. e-commerce storefront was a big responsibility and our multi-disciplinary team rose to the challenge. Our focus was to create a straightforward user experience in which we created branded content, worked with influencerson unique campaigns and implemented strategic advertising to make the Seiko websitecompetitive. We are proud not only of the seamless launch but of the constant evolution of thesite throughout the year.”

Lorem Ipsum provided the creative assets fromvideo to lifestyle photography for all of Seiko’s campaigns throughout the year, most notably for their national campaigns-Prospex StreetSeries and Coutura Car, and designed customized landing pages, e-mail campaigns, and third-party banners that provided a visual narrative of product and lifestyle images.The team’s creative and marketing strategies led to the fastest sellout of a single Seiko product in company history with the launch of the cult classic Alpinist timepiece. “The nominations submitted to the 2019 American Business Awards were outstanding,” said Michael Gallagher, president and founder of the Stevie Awards. “They illustrate the continued vibrancy of innovation and high level of achievement across the American economic landscape.” More than 3,800 nominations from organizations of all sizes and industries were submitted for consideration in a wide range of categories. More than 250 professionals worldwide participated in the judging process to select this year’s Stevie Award winners.

ABOUT LOREM IPSUM

Lorem Ipsum is a multi-disciplinary firm specializing in the planning, design and production of experiences. Our work includes museums, exhibits, immersive shows, visitor attractions as well as all types of filmed and interactive media.

Founded in 2000, the company is headquartered in New York, with offices in London and Moscow. Our global team of over forty professionals includes writers, filmmakers, designers, architects, technologists and researchers.

At Lorem Ipsum, they think of themselves as storytellers. They believe in the power of dramatic narratives. They use words, pictures, music, artifacts, physical props, live performance, lighting, sound design, video, animation, games, social media, virtual and augmented reality to tell engaging stories and create emotional experiences.

For more information on the award or Lorem Ipsum’s work, please visit http://www.loremipsumcorp.com

ABOUT THE STEVIE AWARDS

Stevie Awards are conferred in seven programs: the Asia-Pacific Stevie Awards, the German Stevie Awards, The American Business Awards®, The International Business Awards®, the Stevie Awards for Women in Business, the Stevie Awards for Great Employers, and the Stevie Awards for Sales & Customer Service. Stevie Awards competitions receive more than 12,000 entries each year from organizations in more than 70 nations. Honoring organizations of all types and sizes and the people behind them, the Stevies recognize outstanding performancesin the workplace worldwide.

Learn more about the Stevie Awards at http://www.StevieAwards.com.

Ls hybrid, Lexus, 360 magazine

LS Hybrid

2019 LS Hybrid: The Rolls-Royce of Lexus

By Yuan Chen × Vaughn Lowery

If you are in the market for an elegant yet bespoke type of vehicle, you definitely should consider the 2019 Lexus LS 500h. As of late, we decided to take this extremely luxurious sedan on a drive around the NYC metropolitan area to rendezvous with our east coast counterparts. Unlike the 2019 Audi A8L, 2019 BMW 740e or 2018 Mercedes-Benz S650, 2019 Lexus LS 500h is a vehicle which is filled with passion, performance and a boat load of technology.

Design

The design team was inspired by traditional Japanese design and culture for the 2019 Lexus LS 500h, offering meticulous craftsmanship with an array of appointments and newly pronounced spindle grille. Outside – the silhouette is sleek and athletic. Inside – the art wood herringbone, ambient lighting and hand pleated trim (reminiscent of origami) makes everyone who enters the cabin feel like Japanese royalty.

“I want those who see the grille to appreciate the design and to wonder at its creation. I want them to be amazed at first glance.”– Lexus Takumi craftsman Yasuhiro Nakashima

It’s astonishing how the company’s master craftspeople were able to fabricate their idea from a single piece of mesh (interlocking L-shaped pieces) into a reality. The complex process of its mouth started with the designer’s pen, and then a computer rendering took it further. But most importantly, the fine-tuning of the final production mold utilized Lexus Takumi craftsman Yasuhiro Nakashima’s highly trained hand. He helped it become more evocative and daring.

Technology

LS Hybrid is loaded with a vast amount of features which are comparable to many top luxury manufacturers such as Apple CarPlay, Amazon Alexa, Lexus Enform Remote, Rear-seat Touchscreen Controls, Satellite radio, WiFi hotspot, Bluetooth capability and Remote Touchpad. Additionally, if you enjoy concert hall sound while driving, upgrade to the Mark Levinson Quantum Logic audio system. With this immersive 2400-watt audio package, the LS 500h provides an unprecedented listening experience for every person in the vehicle. This can be attributed to their 16 channels, 23-speaker injected surround system (four in the ceiling speakers and the largest subwoofer the manufacturer has ever used).

Performance

“The car hovers with both sophistication and poise unlike any other. One of the main reasons we fell back in love with Lexus” – Vaughn Lowery, 360 MAGAZINE

The LS 500 was built on the platform of the high-performance LC coupe, the LS 500 features Lexus’s first-ever twin-turbocharged engine. LS 500 has shared the same turbocharged V6 engine with the newest Audi A8L. However, LS 500h has 354hp with 257 lb-ft of torque (achieving 0 to 60 in just 5.1 secs in RWD or 5.2 secs in AWD). After six generations, the purveyors of this prestige hybrid sedan managed to maintain the industry’s leading benchmark in its class. It’s the first multi-stage hybrid luxury sedan and, contains the instinctive feel of a 10-speed automatic transmission, the most responsive and fastest LS Hybrid with a potent 354 valve Atkinson-cycle gas engine alongside of compact dual electric motors. Their lightest and most compact self battery. If you select different drive modes (from ECO to sport) you can transform from a town car into a spunky 4 seat space ship which rockets into action. With a 22.2 gallon tank, this 3.5L 6cyl gas/electric EVT flagship gets up to 25 mpg city/33 mpg highway.

Safety

LS 500h comes with anti-lock brakes and AWD which aids the vehicle’s ability to turn while braking, effortlessly gripping/stopping on most road conditions/terrains. Also, this model comes well-equipped with airbags: front, knee, overhead and seat side impact for the driver and their co-pilot. Another safety feature worth mentioning are the seat belt pretensioners which automatically tighten straps when abruptly coming to a halt.

Have you ever been on a road trip with traffic and consistently worrying about the sudden stops of the front car? There are no more worries when it comes to 2019 Lexus LS 500h. This model contains features like drivers assist, lane departure assist, park assist and the 360 backup camera which will assist you the best while driving on the highway as well as backing up on tiny roads. While driving in Manhattan in bumper to bumper traffic with pedestrians on all sides, tons of sensors and alerts warned us as people/vehicles (within our blind spots) approached the vehicle. The aforementioned came in handy as this vehicle has a longer wheelbase than its predecessor.

Ergonomics/Additional Features

Best of all, the driver’s seat (28-way adjustable) has 7-massage options for both you and the passenger. This is important for driver’s fatigue on long drives and helps circulate the blood in the lower/upper extremities. Even more, the model also has powered operated privacy screens in the back to block out the sun. Moreover, this model allows you to raise higher and lower by the press of a button so that you can avoid unnecessary scraping while driving up steep driveways.

Not to mention, with the executive package the backseats automatically recline when passengers enter (with ottoman). The climate concierge allows for massage features along with heated/cooling, ventilated seats for added comfort. Most of which can be controlled with the rear seat controls. If this doesn’t make you feel like an emperor/empress, we don’t know what will.

In short, the 2019 Lexus LS 500h is a perfect match for someone whom likes to drive and to be driven – a high profile executive, celebrity and/or a member of an elite dynasty. At approximately $107,000, this vehicle will provoke a certain level of importance. Instead of driving to meetings, most likely meetings will be held inside of it. It’s quiet, smooth suspension as well as hospitable yet intuitive tech make it one of the best in it’s class.

View on Lexus Website here

Ls hybrid, Lexus, 360 magazine

Ls hybrid, Lexus, 360 magazine, Vaughn Lowery

Ls hybrid, Lexus, 360 magazine, Vaughn Lowery

Ls hybrid, Lexus, 360 magazine, Vaughn Lowery

Ls hybrid, Lexus, 360 magazine, Vaughn Lowery

Ls hybrid, Lexus, 360 magazine, Vaughn Lowery

*Photos courtesy of Vaughn Lowery

OTR Releases “Heart”

OTR MAKES HIS ASTRALWERKS DEBUT WITH NEW SINGLE “HEART” FT. SHALLOU OUT TODAY

“OTR produces complex summer tinged pop that begs to be danced to”

The Line of Best Fit

Download / Stream “Heart” Ft. Shallou HERE

View Visualizer HERE

Indie artist OTR has signed to Astralwerks, who released his new single, “Heart” ft. Shallou, today. Shallou’s searing vocals paired with OTR’s evocative piano create a poignant yet ultimately transcendent track with the indelible refrain “We get out alive/in your heart.”

Download / stream “Heart” HERE. View the visualizer HERE.

Shallou an independent artist who has earned SiriusXM #1 spots with tracks like “Lie” and “Begin” and landed on the Billboard Dance charts played “Heart” live for the massive crowd that gathered in the Sahara Tent for his set at both weekends of Coachella 2019.

Ryan, the 26-year old aerospace engineer-turned-producer behind OTR, uncovered his passion for music in 2012, when he began tinkering on a dusty, run-down piano in his college dorm lobby to break up the routine of classes and studying. Shortly thereafter, he picked up a guitar and began experimenting with Logic on his MacBook Pro. Taking an internship in Japan in 2014, he found himself living in the small town of in Kurashiki, with no friends and a major language barrier. To combat the isolation, he purchased a keyboard and a train pass and spent all his free time making music and traveling to bigger cities. When he returned to the States, Ryan moved into a neighborhood on the outskirts of downtown Cincinnati known as “Over-the-Rhine” or OTR. The once-neglected area had undergone a renaissance that mirrored his own journey of discovery as music went from hobby to career goal, so it became the ideal name for his project.

As an independent artist, OTR has released a series of singles and the 2018 EP Unfold, racking up more than 7 million cumulative streams across DSPs. The Line of Best Fit observed, “OTR produces complex summer tinged pop that begs to be danced to.” NYLON noted, “A song called Bliss has a lot to live up to. Luckily [it] achieves just that-tenfold.” Praising his 2018 collaboration with Blondage, “Cold Facts,” Ones To Watch said, “we’re confident with just one push of the play button, you will become an instant devotee.” Last week, Thissongissick premiered OTR’s remix of RKCB’s “Know Love”, and noted, “he has really outdone himself another incredible release.”

ABOUT ASTRALWERKS

Established in New York City and now finding its new home in the historic Capitol Records Tower in Los Angeles, Astralwerks was the brainchild of staffers at Caroline Records who saw an opportunity for a label focused on the emerging electronic and ambient scene. Having reached a milestone of 25 years, Astralwerks has quickly become a modern, artist-first label with a true focus on nurturing talent across the electronic genre and beyond. Acting with a scalable, independent and global thinking mentality with the capability to tap into the resources of a major label, has allowed Astralwerks to retain and sign up-and-coming artists such as I Illenium, Jonas Blue, Alison Wonderland, EDEN, Sigma and Axwell /\ Ingrosso. As a testament to this pioneering approach, Astralwerks has amassed 30 GRAMMY nominations, taken home six GRAMMY Awards and had historic releases from the likes of The Chemical Brothers, Swedish House Mafia, Halsey, Porter Robinson, Phoenix, Eric Prydz, Fatboy Slim and many more.

Follow OTR on Social Media

Instagram I Twitter I FacebookI Website I Soundcloud I Youtube

Casio G-Shock Introduces New MT-G

CASIO G-SHOCK INTRODUCES A NEW CONNECTED MT-G IN VIBRANT RED COLORWAY

Latest Model Unveils New Band and Case Structure with Colorful Accents for Spring  

Today, Casio G-SHOCK announces the latest timepiece to join its luxury men’s MT-G line. The MTGB1000B-1A4 features an all-new bright red urethane band, as well as black IP case with silver and red accents on the dial to provide a combination of style, toughness and practicality.

G-SHOCK’s premium MT-G line adds a hint of sophistication to any look, with the latest watch from the series offering striking red details, the brand’s Tough Movement technology and a lightweight core guard structure, featuring box frame with a carbon-fiber reinforced resin case for a design that can comfortably be worn from day to night.

The MTGB1000B-1A4 includes Two-Way Time Sync technology, which combines self-adjusting Multi-Band 6 Atomic timekeeping and Bluetooth connectivity, which pairs with the G-SHOCK Connected App for an accurate hour/date display virtually anywhere on the globe. The timepiece also boasts tough solar technology for self-charging capabilities and premium features found within all MT-G models, including Triple G Resist to guard against shock, vibration and centrifugal forces, and sapphire crystal to enhance scratch resistance.

The MTGB1000B-1A4 comes equipped with G-SHOCK technology including:

  • 200M water resistance and shock resistance
  • Super Illuminator
  • Dual Dial Display
  • Super Illuminator LED Light
  • Stopwatch and countdown timer
  • Daily alarm
  • Full auto calendar
  • World time (39 TZ + 27 cities)

The MTGB1000B-1A4 will retail for $900 and be available for purchase beginning in May at select high-end jewelers and gshock.com.

About G-SHOCK

CASIO’s shock-resistant G-SHOCK watch is synonymous with toughness, born from the developer Mr. Ibe’s dream of ‘creating a watch that never breaks’. Over 200 handmade samples were created and tested to destruction until finally in 1983 the first, now iconic G-SHOCK hit the streets of Japan and began to establish itself as ‘the toughest watch of all time’. Each watch encompasses the 7 elements; electric shock resistance, gravity resistance, low temperature resistance, vibration resistance, water resistance, shock resistance and toughness. The watch is packed with Casio innovations and technologies to prevent it from suffering direct shock; this includes internal components protected with urethane and suspended timekeeping modules inside the watch structure. Since its launch, G-SHOCK has continued to evolve, continuing to support on Mr. Ibe’s mantra “never, never give up.” www.gshock.com

About Casio America, Inc.

Casio America, Inc., Dover, N.J., is the U.S. subsidiary of Casio Computer Co., Ltd., Tokyo, Japan, one of the world’s leading manufacturers of consumer electronics and business equipment solutions. Established in 1957, Casio America, Inc. markets calculators, keyboards, mobile presentation devices, disc title and label printers, watches, cash registers and other consumer electronic products. Casio has strived to realize its corporate creed of “creativity and contribution” through the introduction of innovative and imaginative products. For more information, visit http://www.casio.com/home.

AIRism

UNIQLO x alexanderwang AIRism Collection is now available in stores and online at Uniqlo.com!

The 2nd collection with Alexander Wang builds on the LifeWear commitment to making life better by joining the exceptional functionality of UNIQLO’s innovative AIRism fabric with Alexander Wang’s sleek styling. It includes 11 AIRism styles for women and 4 AIRism styles for men of various colorways, made out of the iconic light fabric that is comfortable and smooth for every day wear.

Appropriate Protein Intake

Okayama University research: Estimating appropriate protein intake

In a recent study published in eLife scientists at Okayama show how proteins can hamper an organism’s growth

Biochemists have shown that very high protein levels can be harmful to cells in the human body. However, exactly which proteins fall under this category remains a mystery. Mr.Yuichi Eguchi (graduate student) and Associate Professor Hisao Moriya’s research team at Okayama University recently reported a framework for discriminating between which proteins are toxic at excessive levels and which are not.

The theory behind this phenomenon, also known as the protein burden, is that accumulation of excessive protein within the cell will deplete the cell of resources, such as energy. The limit required to reach this burden though, is not the same for all proteins. Green fluorescent protein (GFP) is a harmless protein artificially introduced into cells for visualizing the insides of the cell. When GFP levels were increased within yeast cells, they found that GFP up to 15% of total protein content was harmless to the cells. Using this measure as a standard, Associate Professor Hisao Moriya’s team set out to estimate the burden limit of functional proteins in the cells. 29 proteins essential for energy production were subsequently over-produced.

While many of these proteins also had limits close to 15%, suggestive of their harmless nature, some of the proteins showed growth retardation and other unpleasant effects at lower levels. One such protein was found to accumulate within the mitochondria. Clogging the mitochondria prevents cells from producing oxygen. Another protein was found to undergo structural changes and aggregate into big pieces. Another reason for some of these proteins having a low burden limit, was due to metabolic disturbances induced when they were produced even slightly higher than usual. When these proteins were inactivated by mutations, their burden limit increased. Lastly, the researchers also found that certain proteins showed growth retardation, even at very low levels. Further investigation revealed that such proteins are programmed to remain at inherently low levels. Therefore, even small changes to their concentrations can be dangerous.

This study paved a framework for biologists to make distinctions between proteins based on how toxic they are when present in abnormal amounts. These differences could be attributed to the function, structure or genetic programming for that protein. Scientists can hope to use this framework to investigate proteins that are associated with diseases such as Alzheimer’s disease or Parkinson’s disease.

Background

The protein burden: Each protein has a distinct function within cells. Proteins are found in millions within the cell, and are synthesized or increased when required. Their levels subside when the cell doesn’t require them anymore. In certain conditions, such as neurodegenerative disorders, the levels of some proteins inherently remain high. Because the cell is not used to this, a battle to reduce these proteins ensues. This not only uses up the cell’s energy but damages the cell in the process.

By measuring the expression level that causes growth defect (expression limit), Eguchi and Moriya established a framework to distinguish harmful proteins from harmless proteins upon overexpression. They also found that some proteins were harmful upon overexpression because; they form aggregation through cysteine residues (S-S bond), they are transported into mitochondria, and they trigger metabolic perturbation.

About Okayama University

Okayama University is one of the largest comprehensive universities in Japan with roots going back to the Medical Training Place sponsored by the Lord of Okayama and established in 1870. Now with 1,300 faculty and 13,000 students, the University offers courses in specialties ranging from medicine and pharmacy to humanities and physical sciences. Okayama University is located in the heart of Japan approximately 3 hours west of Tokyo by Shinkansen.

Lexus IS 350 F Sport

By Tara McDonough × Vaughn Lowery

As of late, 360 MAGAZINE took a road trip from Los Angeles to Palm Springs in the new 2019 Lexus IS 350 F Sport. The Friday midday drive took around 3 hours with heavy traffic and the Lexus handled like a dream, providing a comfortable and quiet ride.

With a red carpet ready exterior combined with the public presentation and speed of a cheetah, the $53,000 2019 Lexus IS 350 F Sport effortlessly combines luxury and performance. The clear and alluring looking vehicle makes a bold statement for Lexus brand sedans. The vehicle is intuitive and dynamic with brakes that feel stronger and suspension that feels tighter.

PERFORMANCE

The IS 350 F Sport gets a combined 23 mpg city/hwy. It uses 4.3 gallons per 100 miles. With a 311 horsepower and 280 pound-ft of torque, the Lexus leaps across the pavement, while maintaining a smooth ride. The vehicle is fitted out with a 3.5-liter V6 24-valve, dual overhead cam, direct injection, adaptive variable suspension and variable timing intelligent wide intake and exhaust. It boasts an 8-speed sport shift transmission with driving modes such as ECO, normal, sport and snow. The visibility and force in a car this size is impressive combined with less road vibration and responsive brakes. Very reminiscent of the 2003 Infiniti G35, Lexus really does it all in this 2019 IS 350 F Sport.

EXTERIOR

The appearance of the IS 350 F Sport combines dark chrome with a pronounced mesh grille which pairs nicely with its large black 18’’ split 5-spoke wheels. The motorcar is a compact and speed oriented vehicle enhanced with triple beam headlights.

INTERIOR

The inside holds a geometric style allowing for a sturdy yet cozy appearance. The sharp black interior is matched with leather and imitation grain wood paneling. It’s bolstered F Sport seating is heated and ventilated as well. In addition to its leather stitching, the left and right positions of the steering wheel are manually heated as well. This model comes with the classic F Sport gauge which which is controlled by the tinge of a button. Back seats fold down for additional storage, making the IS 350 F Sport the only Lexus Sedan model with the option.

SAFETY & TECHNOLOGY

The Lexus IS 350 F Sport received government 5-Star Safety Ratings in Overall Vehicle Score, Frontal Crash, Side and Rollover. It owes its safety capabilities mainly to the technology implanted into it.

Just a few aspects of the Lexus’s technology which works to ensure the safety of passengers are it’s blind spot monitor with rear cross traffic alert, it’s intuitive parking assist and the Lexus Enform Safety Connect & Service Connect. Other mentionable features include the Lexus Safety System+ which includes a pre-collision system with pedestrian detection, high speed-dynamic radar cruise control, lane departure alert with steering assist and intelligent high beam headlights. This model also takes into account the safety of our environment with a Fuel Economy & Greenhouse Gas Rating of 5 due to it’s eco mode gas saver. Due to this feature the 360 team was able to race from Los Angeles to Palm Springs and back with animalistic stamina and no need to refill the tank.

The IS 350 F Sport Model also comes equipped with a Mark Levinson audio which includes a navigation System with 10.3-in Color Multimedia Display, Mark Levinson 15 speaker and 835 Watt, 5.1-channel Surround Sound Audio System. In addition to the audio package the model comes with voice command, siri eyes free and Scout GPS Link TurnStrem(™).

CONCLUSION

The Lexus IS 350 F Sport is a vehicle made for successful self-motivated individuals who have a strong appreciation for extremely dynamic vehicles while additionally having the capabilities to comfortably seat five. Nevertheless, Lexus truly has found a means to win back car enthusiasts with this newly imagined entry level sports sedan.

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360 magazine, Lexus, is 350, f sport

360 magazine, Lexus, is 350, f sport

360 magazine, Lexus, is 350, f sport

G-SHOCK Collabs with Blue Note Records

Casio G-SHOCK Unveils Collaboration Model With World-Renowned Jazz Label, Blue Note Records

New Model Features Sleek All-Black Look with Blue Accents to Celebrate Label’s 80th Anniversary

Casio G-SHOCK unveils a limited-edition men’s watch made in collaboration with the legendary Jazz label, Blue Note Records. Created to honor Blue Note’s 80th anniversary, the latest model is an updated take on G-SHOCK’s popular G-STEEL line of men’s high-end timepieces and arrives in a sleek black colorway with blue accents on the dial, and buckle, as well as an IP case back, button and band keeper. The watch comes with custom limited-edition packaging.

Boasting the classic G-STEEL look, the GSTB100BNR-1A combines refined style with durability and practicality. The unique timepiece nods to both iconic brands by featuring bright blue accents and engravings of the G-SHOCK and Blue Note logos.

“Blue Note and G-SHOCK have a history of refinement and shifting culture,” said Don Was, President of Blue Note Records. “We felt G-SHOCK was the right partner to help us celebrate our 80th anniversary while we usher in a new era at the label. It’s about bringing our audiences together and giving them something they can love, whether they’re a Jazz aficionado or a hip-hop lover.”

A video was created to celebrate the launch of the new G-SHOCK x Blue Note Records timepiece, starring Blue Note artists Charles Lloyd, Kendrick Scott, and lophiile. Watch here.

Additionally, you can stream the playlist Daddy Kev’s Blue Note X G-SHOCK Mix that was inspired by the collaboration.

The GSTB100BNR-1A not only provides an upscale look, but it also comes equipped with several of G-SHOCK’s most sought-after features including solar-powered charging capabilities, a super LED light and Neo-Brite luminous hands for maximum visibility. Additionally, the GSTB100BNR-1A boasts Bluetooth low energy technology to pair with smart phones via the G-SHOCK Connected App.

The new model also comes equipped with G-SHOCK technology such as:

  • 200M water resistance
  • Shock resistance
  • World Time/dual time display
  • 1/100th Sec. Stopwatch
  • Countdown Timer
  • Daily alarm

The limited-edition GSTB100BNR-1A will retail for $420 and will be available for purchase starting this March at select jewelers, fashion boutiques, the G-SHOCK Soho Store and gshock.com.

About G-SHOCK

CASIO’s shock-resistant G-SHOCK watch is synonymous with toughness, born from the developer Mr. Ibe’s dream of ‘creating a watch that never breaks’. Over 200 handmade samples were created and tested to destruction until finally in 1983 the first, now iconic G-SHOCK hit the streets of Japan and began to establish itself as ‘the toughest watch of all time’. Each watch encompasses the 7 elements; electric shock resistance, gravity resistance, low temperature resistance, vibration resistance, water resistance, shock resistance and toughness. The watch is packed with Casio innovations and technologies to prevent it from suffering direct shock; this includes internal components protected with urethane and suspended timekeeping modules inside the watch structure. Since its launch, G-SHOCK has continued to evolve, continuing to support on Mr. Ibe’s mantra “never, never give up.” www.gshock.com

About Casio America, Inc.

Casio America, Inc., Dover, N.J., is the U.S. subsidiary of Casio Computer Co., Ltd., Tokyo, Japan, one of the world’s leading manufacturers of consumer electronics and business equipment solutions. Established in 1957, Casio America, Inc. markets calculators, keyboards, mobile presentation devices, disc title and label printers, watches, cash registers and other consumer electronic products. Casio has strived to realize its corporate creed of “creativity and contribution” through the introduction of innovative and imaginative products. For more information, visit www.casio.com

Blue Note Records

​Blue Note Records was founded when a German immigrant named Alfred Lion produced his first recording session with two boogie woogie pianists on January 6, 1939 in New York City. Blue Note has gone on to represent The Finest In Jazz, tracing the entire history of the music from Boogie Woogie, Hot Jazz and Swing, through Bebop, Hard Bop, Post Bop, Soul Jazz, Avant-Garde, and Fusion, and into Jazz’s numerous modern day incarnations. Blue Note’s legendary catalog includes a true Who’s Who of Jazz history: Thelonious Monk, Bud Powell, Miles Davis, John Coltrane, Cannonball Adderley, Horace Silver, Art Blakey, Jimmy Smith, Dexter Gordon, Grant Green, Lou Donaldson, Donald Byrd, Lee Morgan, Freddie Hubbard, Joe Henderson, Herbie Hancock, Wayne Shorter, McCoy Tyner, Ornette Coleman, and many more.