Posts tagged with "effectiveness"

Fighting Antibiotic Resistance

To combat the rise of drug-resistant bacteria, researchers are examining how one superbug adapts to fight an antibiotic of last resort, hoping to find clues that can prolong the drug’s effectiveness.

At Rice University and the University of Texas Health Science Center at Houston ran experiments to track the biochemical changes that vancomycin-resistant Enterococci (VRE) underwent as they adapted to fight another antibiotic, daptomycin. “We need to get to a stage where we can anticipate how these pathogens will become resistant to antibiotics so we can stay one step ahead of them,” said Rice biochemist Yousif Shamoo, co-author of a study in the journal Antimicrobial Agents and Chemotherapy that found VRE can develop resistance to daptomycin in more than one way. The stakes are high. In 2014, the World Health Organization reported that antibiotic-resistant infections were on pace to kill 10 million people per year worldwide by 2050.

According to the U.S. Centers for Disease Control, VRE is one of the nation’s leading antibiotic resistance threats. The CDC estimated VRE will infect some 20,000 people in the U.S. this year and kill 1,300 of them. Daptomycin, an antibiotic that first became available in 2003, is one of the last drugs doctors can use to fight multidrug-resistant superbugs like VRE, methicillin-resistant Staphylococcus aureus (MRSA) and glycopeptide resistant enterococci (GRE). Unfortunately, health officials documented cases of daptomycin resistance as early as 2005, and the number of cases is on the rise worldwide.

Shamoo said one of the principle findings of the study was that a specific strain of VRE, Enterococcus faecium, has an unusually diverse set of strategies for resisting antibiotics like daptomycin, and that diversity can make treatment of infections even more difficult. “By understanding how these pathogens acquire resistance, we can develop new treatment strategies or new ‘co-drugs’ that target their ability to become resistant,” Shamoo said. Co-drugs that target the evolution of resistance could be administered with antibiotics like daptomycin to both help patients fight off infection and stem the spread of increasingly resistant strains of bacteria in hospitals, he said.

Study lead author Amy Prater, a Ph.D. student who graduated from Rice in July, showed that the same strain of VRE could activate different biochemical pathways to activate up to three strategies, depending upon its environment. Shamoo said the multipronged strategy will make it more difficult for health officials to fight growing daptomycin resistance in VRE, but he said the results help clear up previously confusing experimental findings about VRE resistance, which is a step in the right direction. “If we understand how a pathogen acquires resistance, we can anticipate its next move, and hopefully act beforehand to cut it off,” Shamoo said. “Predictability is the key.”

Shamoo is Rice’s vice provost for research and a professor of biochemistry and cell biology in the Department of BioSciences. Additional co-authors include Heer Mehta and Abigael Kosgei of Rice and William Miller, Truc Tran and Cesar Arias of the UTHealth McGovern Medical School.

Kiip’s CEO: March Update

March has been Madness! (In the best of ways)

We’re kiiping busy, and hope you have been too. This year is already flying by and we’ve got so much to share!

 

#PressforProgress & #feff

Kiip is dedicated to supporting and growing an equal and diverse workforce and we know that means having an open and honest conversation about how we can do better. Take a look at what our leaders here at Kiip have to say about progress in 2018.

 

Announcements

&#feff; Kiip Gets Into the Data & Audiences Business

 

Audiences

We’ve been hard at work. Since we launched our Moments Table, many brands have asked if they can use our data more broadly. We finally launched our audiences into (initially) LiveRamp Data Store and now I am happy to report that you can buy moments audiences decoupled with our media.

 

Surveys

On top of this, we rounded out our data suite with our Surveys product. Too often as marketers we are faced with limited 3rd party data options (largely cookie based or too probabilistic). We decided to use our mobile-first positioning and engagement unit in our ads to create a survey product where the marketer can simply ask the consumer (millions of them). With these survey responses we can create seed audiences activated on Kiip (or elsewhere as aforementioned) or simply qualify the success of your campaign. The possibilities are endless.

 

Helpful Content

To help further hammer home the point of why we went into the data business, we put together some helpful content. An interesting tidbit: the VP of Netflix started quite a stir in 2016 when he suggested that demographic data was a thing of the past, or rather headed to the trash. I believe that marketing is heading from a segment-based approach to a signal-based approach. Here’s a post from one of our brilliant strategist Lauren, on how best to ensure that your audience data is used effectively and sourced transparently.

 

Okay so now you’ve read all about how to avoid the pitfalls (in the post linked above), are you ready to talk strategy and leave generic data in the past? Schedule a complimentary session today and learn more about how our audience targeting stands out from the crowd.

 

The Summer Forecast

Every month we release mobile app behavior trends called M.I.C. drops. These help our media buying customers to get ahead of trends and know how to buy more effectively based on what people are going to be spending time doing. The March M.I.C. drop stats are in and it’s sunny with a chance of 2 in 3 teens working this summer. This summer polls 55% of teens working and earning over $1K. We’ve collected the data, now you can make accurate predictions on what they’ll be spending that money on and when. See for yourself how best to reach a teen audience this summer!

 

Case Study Center

 

 

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