A new study released today in STEM CELLS outlines how fat grafting – which previous studies have shown can reduce and even reverse fibrosis (scar tissue) buildup – also improves the range of motion of the affected limb. The study, conducted by researchers at Stanford University School of Medicine, was conducted on mice.
The tumor-destroying capabilities of radiation therapy can be a life saver for a person suffering from cancer. But it’s a therapy that has several unwanted side effects, too, including causing substantial damage not just to cancerous cells, but any healthy tissue in its path. Over time, fibrosis builds up in the treated area which, in the case of an arm, shoulder, or leg, for example, can lead to painful contractures that significantly limit extensibility and negatively impact the person’s quality of life.
The Stanford team irradiated the right hind legs of subject mice, which resulted in chronic fibrosis and limb contracture. Four weeks later, the irradiated limbs of one group of the mice were injected with fat enriched with stromal vascular cells (SVCs). These potent cells already naturally exist in fat, but supplementation of fat with additional SVCs enhances its regenerative capabilities. A second group was injected with fat only, a third group with saline and a fourth group received no injections, for comparison. The animals’ ability to extend their limb was then measured at baseline and every two weeks for a 12-week period. At the end of the 12 weeks, the hind limb skin underwent histological analysis and biomechanical strength testing.
“Each animal showed significant reduction in its limb extension ability due to the radiation, but this was progressively rescued by fat grafting,” reported corresponding author Derrick C. Wan, M.D., FACS. Fat grafting also reduced skin stiffness and reversed the radiation-induced histological changes in the skin.
“The greatest benefits were found in mice injected with fat enriched with SVCs,” Dr. Wan added. “SVCs are easily obtained through liposuction and can be coaxed into different tissue types, where they can support neovascularization, replace cells and repair injured issue.
“Our study showed the ability of fat to improve mobility as well as vascularity and appearance,” he continued. “We think this holds enormous clinical potential — especially given that adipose tissue is abundant and can be easily collected from the patients themselves — and underscores an attractive approach to address challenging soft tissue fibrosis in patients following radiation therapy.”
Furthermore, said co-author and world-renowned breast reconstructive expert Arash Momeni, M.D., FACS, “Our observations are potentially translatable to a variety of challenging clinical scenarios. Being able to reverse radiation-induced effects holds promise to substantially improve clinical outcomes in implant-based as well as autologous breast reconstruction. The study findings are indeed encouraging as they could offer patients novel treatment modalities for debility clinical conditions.
“Excessive scarring is a challenging problem that is associated with a variety of clinical conditions, such as burn injuries, tendon lacerations, etc. The potential to improve outcomes based on treatment modalities derived from our research is indeed exciting,” Dr. Momeni added.
“Skin and soft tissue scarring and fibrosis are well-established problems after radiation. The current study, showing that human fat grafting can normalize the collagen networks and improve tissue elasticity in immune deficient mice, provides molecular evidence for how fat grafting functions,” said Dr. Jan Nolta, Editor-in-Chief of STEM CELLS. “The studies indicate that, with the appropriate regulatory approvals, autologous fat grafting could potentially also help human patients recover from radiation-induced tissue fibrosis.”
Full article HERE.
Dialysis has been obsolete for the past quarter of a century. See article for references.
One of the most critical situations in modern society is being alone in a difficult situation. What do we have to do if you found out that you are alcohol or drug addicted? Surely, the first thing to do if you cannot control yourself is to ask for help. However, sometimes it happens that you have nobody to ask for help or people, who wish to help have no possibilities.
How much does rehab cost without insurance?
Actually, there is no correct answer to this question, because different recovery programs use different techniques, different specialists work with you, they use different medicines, and there are many other different conditions, which determine the price. First, look through the types of rehab facilities to choose the one you need. They may be medical detox centers, intensive outpatient programs, holistic rehab center, partial hospitalization programs, standard outpatient treatment, etc.
To talk generally, inpatient treatment usually costs more than participation in outpatient rehabilitation programmes in Bellevue. It is evident as the inpatient treatment foresees that you live in the facility and use all the conveniences, receive food, get medical supervision. The price also depends on how long you stay in the rehab facility and what other services and amenities you require (private rooms, swimming pool, gym, massage, etc.).
One is tempted to ask the question of what to do if you have no opportunities to pay for your addiction treatment? Is that possible to get help for addiction without insurance?
Different social programs may cover your expenses for the rehabilitation programme partially or fully. First, if there are some life-threatening risks of consuming some substance, you would receive emergency treatment and regardless of whether you can pay or not. Hopefully, you will not get into such a situation.
There also exist some options for flexible payment. They may be scholarship, grant, financing, etc. It is important to note here is that cutting corners on recovery programme may turn into future problems. It is of utter importance to reclaim your health and life. The fact is that you would spend more money on drugs or alcohol if you continue succumbing to the addiction than on any rehab for people with no insurance (find more here).
Do not be too lazy to call several recovery centers and find out what conditions of payment they have. First, many treatment facilities may offer reduced treatment costs or a sliding fee scale because of the pieces of evidence that you do not make high enough income.
Secondly, there exist some non-profit organizations or foundations, which may offer you some scholarships. Usually, one of the conditions of getting a scholarship is the absence of insurance. Application for such programs may give you the way to rehab for people with no insurance.
Thirdly, depending on your credit score, you may ask some lending institutions for providing drug or alcohol treatment without insurance. The specifications of such cooperation differ in each personal case.
Fourthly, do not be too shy to ask your friends and relatives. Sometimes they do not even know that you need this sort of help. Doctors say that involving family members into the process of recovery may make you closer and you would definitely feel more support. This may also change the views of your family on the attitude before and make it more integrated. A friend at court is better than a penny in purse.
To sum up, do not be afraid of sharing your problems. In the modern world, many people feel sympathy for those, who cannot afford treatment, so the only thing you have to do is to ask.
Jeffrey Buckley is a blogger who investigates human health issues and behaviorist anthropology. He researches substance abuse problems and the ways to overcome addictions.
RIP Medical Debt (RIPmedicaldebt.org) first gained public attention in 2016 when John Oliver on HBO made television history by announcing forgiveness of $15 million in medical debt by RIP. This news event blossomed into a tremendous outpouring of support for the charity. In the May 2018 issue of Town and Country magazine, RIP Medical Debt was listed as #38 among the top philanthropists in America. RIP Medical Debt most recently announced a single campaign abolishing a quarter-billion dollars ($250 million) of medical debt in all 50 states, including $50 million for abolishing veterans’ medical debt. Overall, by the end of 2018, RIP will have forgiven more than a half-billion dollars of unpayable medical debt since the charity was founded four years ago.
END MEDICAL DEBT by the founders of the charity, RIP Medial Debt, is the first book exposing the widely overlooked reality that Americans struggle with $1 trillion in unpayable medical debt. We hear a lot of talk about healthcare gaps and medical costs, but the media have largely been ignoring how medical debt imposes a devastating burden on people’s lives!
End Medical Debt’ confronts an important, sad truth: no one asks to be sick. It’s hard enough being poor; it’s hard enough being sick. But being poor and sick becomes a death sentence for some, and a life sentence to indentured servitude for others.
The authors — Jerry Ashton, Robert Goff, and Craig Antico — are debt industry insiders who lay bare the inner workings of our healthcare system, how it produces medical bills that people cannot ever pay, including insured middle-class people who think they are covered. Voicing decades of experience in debt collections, debt buying and healthcare management, the authors offer pragmatic yet differing views on such solutions as cost controls, insurance reform and “Medicare-for all.” All three agree on the interim solution of buying and forgiving medical debt.
On Veterans Day, RIP announced the forgiveness of $50 million in unpaid and unpayable medical debt as a part of a major donation by a single donor couple. We compute that this amount of medical debt for veterans will impact close to 29,000 individuals and families.
It may be hard to believe, but veteran medical debt really exists. It is almost a common understanding that medical costs for our armed forces and their families, both during and after enlistment, are paid by the government in return for their service to our country.
Unfortunately, that’s not the case. One visit to the emergency room or treatment for a serious illness outside (and even inside) the VA can devastate a vet’s savings and credit ratings.
Madonna is currently visiting Malawi, where she has worked since 2006 with her charitable organization, Raising Malawi. The musician and philanthropist is marking the first anniversary of the Mercy James Centre for Paediatric Surgery and Intensive Care, an ambitious project undertaken by Raising Malawi to improve specialized paediatric healthcare in Malawi. Located on the campus of Queen Elizabeth Central Hospital (QECH) – the largest referral hospital in the country – the Mercy James Centre includes Malawi’s first paediatric intensive care unit, three operating theatres dedicated to surgery in children, a day clinic, and 50-bed ward.
“Malawi is a second home for me and my family, and every time we come here is a homecoming. It’s a thrill to celebrate the one-year anniversary of the Mercy James Centre, its talented staff, and the committed partners who have worked with Raising Malawi to make this effort a success,” said Madonna. “Our achievements this past year have exceeded our expectations, and we will continue with our mission to better serve the children of this country.”
Raising Malawi funded the Mercy James Centre for Paediatric Surgery and Intensive Care (MJC) to provide Malawi’s youth with the best medical care possible. Since opening July 11, 2018, the talented staff of Mercy James Centre have:
- Performed 1,690 paediatric surgeries – more than double the annual average before the Mercy James Centre
- Admitted nearly 300 patients into the paediatric ICU
- Seen 2,300 patients in the outpatient clinic
- Admitted nearly 1,500 patients into the ward
The MJC is setting a new standard of paediatric surgical and intensive care in the region. Highlights from year one include Malawi’s first successful operation of conjoined twins. A team of 20+ doctors, nurses and anesthesia staff, led by long-time Raising Malawi partner Dr. Eric Borgstein, successfully separated two baby boys. The effort was a testament to spirit of collaboration and excellence that is imbedded in the culture of Mercy James Centre.
“We are able to tackle cases that we never could have done in the past. Because of the Mercy James Centre, we are saving more children’s lives, particularly those with complex medical issues. The support of Madonna and Raising Malawi has transformed paediatric surgical and intensive care in Malawi,” said Dr. Borgstein.
In addition to increasing paediatric surgical capacity, the Mercy James Centre is growing into its role as a training center of excellence. It houses the sole paediatric surgery training program in Malawi, supported by Raising Malawi. Partners like Physicians for Peace and Oslo University Hospital drive bedside education in the paediatric intensive care unit (PICU), the first PICU in Malawi.
Madonna is also a global leader in promoting education for the world’s most vulnerable children. In 2012, she launched a partnership between her foundation, Raising Malawi, and the global nonprofit buildOn. Today, Madonna has served nearly 10,000 Malawian students – fulfilling her commitment to making learning and school accessible to Malawian youth. During her latest trip, Madonna traveled to Northeast Kasungu Province to officially open four primary schools constructed with buildOn – in total Raising Malawi has built 14 schools in rural Malawi. As a part of the partnership, Raising Malawi and buildOn have educated community members about the importance of girls’ education, and as result, all schools have gender-parity (equal numbers of girls and boys enrolled).
Madonna concluded the trip with a meeting with His Excellency President Arthur Peter Mutharika, who appointed her Malawi’s Goodwill Ambassador for Child Welfare in 2014.
About Raising Malawi
Madonna founded Raising Malawi in 2006 to address the poverty and hardship endured by Malawi’s orphans and vulnerable children. Raising Malawi partners with local organizations to provide Malawian children and their caregivers with critical resources including education and medical care. http://www.raisingmalawi.org
At home or abroad, buildOn’s goal is to break the cycle of poverty, illiteracy and low expectations through service and education. Across the U.S., buildOn empowers urban youth to transform their neighborhoods through intensive community service and to change the world by building schools in some of the economically poorest countries in the world. Since 1991, buildOn has constructed 864 schools worldwide, with more than 110,000 children, parents and grandparents attending these schools every day. For more information, visit www.buildon.org. buildOn has a 4-star rating from Charity Navigator.
NEW YORK, June 12, 2018/PRNewswire/ -In honor of the reopening of its location at The Mall of San Juan, H&M is proud to make a $200,000 donation to San Jorge Children’s Foundation.
In anticipation of the June 7th reopening of its location at The Mall of San Juan, in San Juan, Puerto Rico, H&M supported the local community through San Jorge Children’s Foundation. H&M first partnered with nonprofit GLAM4GOOD and donated over 2,000 articles of clothing for a free pop up shop held at San Jorge Children’s Hospital on May 23rd for patients and their families, as well as doctors and nurses of the hospital. Building upon this initial outreach, sale proceeds from both Puerto Rican H&M locations during June 7th -10thwere donated to San Jorge Children’s Foundation, amounting to a donation of $200,000.
“We are so thrilled to help the local community in Puerto Ricowith this donation to San Jorge Children’s Foundation,” said Daniel Kulle, North American President of H&M. “We are also happy to be reopening our first location on the island for our customers and employees.”
H&M opened its first location in Puerto Rico at The Mall of San Juan on June 9th, 2016 and its second location at Plaza del Sol in Bayamón on September 1st of the same year. The company currently employs approximately 50 people on the island of Puerto Rico and is proud to support the local community.
The GLAM4GOOD Foundation is a non-profit organization that creates and celebrates social impact and empowerment through beauty and style. The foundation partners with non-profits, media outlets and fashion and beauty brands to provide life-changing makeovers, clothing giveaways and confidence-bolstering fashion and beauty initiatives for everyday heroes and people in need.
San Jorge Children’s Foundation is a nonprofit organization dedicated to the health and welfare of children in Puerto Ricowith the aim to help improve patient’s quality of life. The foundation is committed to providing services for families in need and has a network of more than 1500 active patients.
For more information on San Jorge Children’s Foundation:
For more images of the opening:
About The Mall of San Juanlocation:
H&M, Hennes & Mauritz (H&M) at The Mall of San Juan is located at 1000 The Mall of San Juan Blvd, San Juan, PR 00924. The store can be reached by phone at (855) 466-7467. Store hours will be Monday through Thursday 10:00 a.m. – 7:00 p.m., Friday and Saturday 10:00 a.m. – 9:00 a.m. and Sunday 11:00 a.m.– 7:00 p.m.
H & M Hennes & Mauritz AB (publ) was founded in Sweden in 1947 and is quoted on Nasdaq Stockholm. H&M’s business idea is to offer fashion and quality at the best price in a sustainable way. In addition to H&M, the group includes the brands COS, Monki, Weekday, Cheap Monday, & Other Stories and H&M Home as well as ARKET. The H&M group has 47 online markets and more than 4,700 stores in 69 markets including franchise markets. In 2017, sales including VAT were SEK 232 billion. The number of employees amounts to more than 171,000. For further information, visit about.hm.com.
Web Site: http://hm.com
The advisory panel to the Food and Drug Administration voted 5-to-4 to reject a claim from Philip Morris International Inc. that “Switching completely to IQOS presents less risk of harm than continuing to smoke cigarettes.” Phillip Morris claims that using their IQOS device, which heats tobacco rather than burn it, could reduce the risk of tobacco related health issues compared to cigarettes.
“How many more smokers will have to die on the FDA’s watch until they catch up to the rest of the world when it comes to supporting harm reduction technologies?” Director of Government Relations John Nothdurft said. “The rest of the world is far ahead of the United States in terms of supporting policies that help smokers quit or at a minimum move to less harmful alternatives such as heat-not-burn products, e-cigarettes, and snus.”