Posts tagged with "Cannabis"

CBD: A Neuroprotective Wonder

Over the past century, neurodegenerative illnesses have significantly increased, and some researchers believe that they will become even more prevalent going forward. A study on Alzheimer’s disease and dementia released in December 2017 suggested that 15 million Americans will suffer from either condition, or “mild cognitive impairment” by 2060, an increase of more than 150 percent on current numbers.

Neuroscience has lagged behind other fields of medicine, with the complexity of the brain proving a difficult code to crack for researchers. The demand for neuroprotective treatments to conserve the health of the brain and stave off mental illnesses caused, at least in part, by brain inflammation is great, but treatments have been hard to come by. However, cannabinoids, an uncommon but seemingly critical set of compounds found in strains of cannabis, have exhibited some intriguing neuroprotective effects in the few studies we have available.

The endocannabinoid system is responsive to these cannabinoids and appears to be neuroprotectant in enhancing deep sleep by regulating the sleep-wake cycle, and by reducing brain inflammation, which endocannabinoids can do by tweaking immune system response.

In this post, we’ll explore in-depth a few of the ways that CBD is an effective neuroprotective drug, with focus on slowing the progression of neurodegenerative illnesses, limiting the damage following brain injuries and facilitating neurogenesis in important parts of the brain, which may hold the key to alleviating depression.

CBD for neurodegenerative diseases

Huntington’s disease, Alzheimer’s disease, Parkinson’s disease and dementia are all types of neurodegenerative illness. Nerve fiber damage occurs naturally due to aging but is also accelerated by these neurodegenerative diseases, as myelin sheath deteriorates – but it appears that CBD can halt or at least stifle this unhelpful process.

Deterioration of the myelin sheath causes a loss of cognitive function and memory, and in the case of Parkinson’s leads to a loss of motor control, hence the uncontrollable and prevalent tremors. While tremors are common among the elderly due to unavoidable neurodegeneration, these are not as severe.

Just recently, a Brazilian doctor was granted a special license by the country’s government to prescribe CBD oil to a patient diagnosed with Alzheimer’s disease. Brazil has been a hub for medical cannabis research in South America, and in particular for studies on the brain.

Sleep is neuroprotective

Mental and physical health problems arise when the body doesn’t get enough sleep, and adults attempting to regularly get by on fewer than the recommended minimum of seven hours are likely to experience fatigue. Conditions such as insomnia and sleep apnea contribute to a lack of sleep and waking up during sleep, but there are other factors that stop the mind from winding down, including anxiety, depression, stress and physical pain.

Thankfully, slow-release CBD products like CBD gummy bears boost sleep and influences the sleep-wake cycle to promote more regenerative deep sleep, and also treats the aforementioned quartet of sleep-preventing symptoms. CBD is also effective for epilepsy patients who suffer from seizures and spasms which keep them awake at night.

Deep sleep is much more important than rapid-eye movement (REM) sleep, a considerably lighter phase of sleep where we have dreams and nightmares. It is only in deep sleep where cerebrospinal fluid, which usually cushions the brain from the outside, enters the brain and flushes away neurotoxins responsible for neurodegeneration. Deep sleep also helps with the production of new cells all over the body. The all-round rejuvenation in this phase is crucial for combatting fatigue.

Reducing and limiting brain damage

Over the past few decades, cannabis has typically been accused of being bad for the brain, with its psychoactive effects triggering mental health conditions such as psychosis. But the studies on CBD have found the opposite, and in fact, administering CBD after a stroke or traumatic brain injury (TBI) may reduce the overall brain damage.

CBD is an antioxidant as well as an anti-inflammatory, which is important as oxidation in the brain has been linked to DNA damage of cells in the organ.

The brain damage that occurs from strokes is referred to as ischemic injury, and the death of brain cells can cause localized paralysis and a loss of speech. The quicker someone suffering from a stroke is treated, the less severe the damage is. Studies have found that the endocannabinoid system is active during a stroke, and that limiting the number of inflammatory cytokines released could be essential to protecting motor control and cognitive function.

Neuroprotection, neurogenesis and treating depression

Research into depression has advanced in the 21st century, although pharmaceutical treatments for the mood disorder, which affects 300 million globally, are still below par. Selective serotonin reuptake inhibitors (SSRIs), the most widely-used and recent class of antidepressants, can take weeks before benefits begin to show, cause side effects such as insomnia, nausea and impotence, and for some patients do not even work.

However, CBD has been found to elevate mood by promoting anandamide in the endocannabinoid system and agonising the 5-HT1A receptor in the serotonin system. And in 2016, evidence was produced showing CBD and another non-psychoactive cannabinoid called cannabichromene (CBC) to have neurogenesis effects in adult rats, helping to stimulate growth in the hippocampus. This is important, as long-term depression causes shrinkage in this part of the brain.

In 2018, a team of Brazilian and Danish researchers found CBD to be an effective medication for depression in rats from the first dose, with therapeutic effects lasting for a week after treatment was stopped. The study revealed that the number of synaptic proteins in the prefrontal cortex eventually increased, a sign that the antidepressant effects had worn off. Past research has connected a rise in these proteins to depression. Therefore, according to one professor on the study, CBD repairs neuronal circuitry in the prefrontal cortex which becomes damaged due to depression.

CBD vape oil and e-liquid and CBD edibles are both useful products for managing neurodegeneration. However, conditions with acute symptoms must be remedied more quickly, and in those situations, vaping e-juice or taking CBD oil provides the most benefit.

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Fetch: CBD For Pets

Numerous international studies suggest that CBD may be beneficial for pets with issues such as anxiety, inflammation, seizures generalized pain, nausea and inappetence. New Fetch tinctures which some in two bottle sizes depending on the size of your pet) contain full-spectrum CBD obtained through CO2 extraction from American-grown industrial hemp. There is no THC (the chemical in marijuana that produces a “high” sensation) and therefore no psychoactive effects. Safe and gentle for beloved pets, each Fetch formula is third party lab-tested for potency and residual solvents. All of the plant material used is tested for heavy metals, pesticides and herbicides.

The company was started by a Boulder, Colorado-based full-service hemp extraction lab (founded in 2016 by combat veteran, Craig Henderson) called Extract Labs. It’s a great product to use to chill out your pet if they have anxiety, have to travel or are in stressful situations. For older pets, it’s also fantastic for joint and muscle pain.

Rosette Luve x Jason Matlo

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Photo Credit: Jamie-Lee Fuoco

Cannabis took over the red carpet at this past weekend’s iHeartRadio VVMA’s! Canadian pop star, Rosette Luve strolled the red carpet wearing an iconic cannabis-inspired dress created by Canadian designer, Jason Matlo for the Weekend Unlimited, a Vancouver-based cannabis brand.

This “smoking hot” dress was specially designed to celebrate the country’s upcoming entry into the legal cannabis market in October! Rosette, who was at the event to promote her own chart single, Single for the Summer, and her dress caught the eyes of a number of other pop artists including Alessia Cara, Bebe Rexha and Shawn Mendes to name a few.

According to the designer, Jason Matlo, “Having the opportunity to design this bespoke version of The Weekend Unlimited dress for Rosette Luve to walk the red carpet of the MMVA’s in Toronto was very exciting. This first design allowed me to merge my background and love of couture with a young, high style street look. The entire process has been very energizing. I will be working creatively on developing a range of products for the Premiere Global Lifestyle brand, Weekend Unlimited Live International.”

Does Smoking Marijuana Cause Lung Cancer?

We all know we’re not supposed to smoke cigarettes – the correlation between smoking and lung cancer is clear. But we live in a society that perpetuates the idea that smoking weed is not as harmful, or not harmful at all.

Dr. Raja Flores, Chairman of the Department of Thoracic Surgery for the Mount Sinai Health System, has a drastically different view on the subject.

In an exclusive video recently published on SurvivorNet, the new definitive source for information about cancer from the world’s leading doctors and cancer centers, Dr. Flores weighs in on why he believes smoking marijuana has a direct correlation with lung cancer. **

He says:
“There is no real good population-based study that looks at marijuana smoking and that has had enough time elapsed to show its associated with lung cancer, [but] I’ve seen it. I’ve seen multiple, multiple cases of it. I see it every day,” Dr. Flores says.

Dr. Flores predicts that once marijuana becomes an accepted part of American culture, the risks associated with smoking will become more clear. “What you’re going to see going down the line is the reincarnation of the whole tobacco disaster,” he says. “I see it now already.”

Due to the excitement surrounding the legalization of both medical pot and recreational pot, the lack of studies on the issue makes sense. This is a multi-billion dollar industry, and a lot of people stand to make a lot of money off of marketing marijuana. “Big business and the money influence is taking precedence over the health issues,” Dr. Flores warns.

You can see the full interview and a transcript of the video here: https://www.survivornet.com/articles/smoking-marijuana-may-cause-lung-cancer/

** DISCLAIMER: THE LACK OF GOOD DATA ON THIS TOPIC MEANS FOR THE MOMENT, THIS IS JUST THE INFORMED OPINION OF DR. FLORES, WHICH CAN’T BE APPLIED ACROSS A WHOLE POPULATION OF POT-SMOKERS.

Story credit: https://www.survivornet.com/

Legalise Medical Cannabis symposium

Held at Portcullis House, Westminster at 7pm on Wednesday 27th June, the symposium took place ahead of the 2nd reading of the debate on the proposed bill of legalisation of Cannabis (Medicinal Purposes) in the House of Commons scheduled for July 6th.

In light of Sajid Javid’s intervention last week, granting permission for two mothers to legally use cannabis to treat their children in the UK and launching a review into medical uses of cannabis, the symposium of experts deliberated the benefits of cannabis-based medicine and called for change in the legal status of the drug for medicinal use in the UK.

The symposium consisted of five individuals invested in changing this law: Damian Jr Gong Marley, Professor Green, Norman Lamb MP, Dr Frank D’Ambrosio and Change.org activist Kate Rothwell.

Damian Jr Gong Marley, the legendary Grammy award winning reggae artist, and youngest son of Bob Marley is an advocate of the medical benefits of cannabis. In 2016 Damian partnered with Ocean Grown Extracts to buy a former prison in California, the Claremont Custody Centre, to turn it into a farm producing cannabis oils, extracts and other products for medicinal use.The music video for Damian’s recently released single Medication, which features his brother Stephen Marley, was shot in the former prison and stars former inmates and includes testimonials from people who’ve been helped by the plant including as US Marine Crops Sergeant Sean Major who uses cannabis for brain trauma and PTSD.

Damian Jr Gong, Marley spoke on the growing scientific evidence for the benefits of cannabis: It’s been a big part of my culture from ever since. A big part of Jamaican culture, reggae music and my faith as a Rasta. Itߣs a big part of my culture. Even before proof of the medical benefits of the plant, we were always endorsing the plant. We use it as a spiritual sacrament and recreationally. We have a saying in Jamaica that: The herb is the healing of the nation. With it becoming legal in various places, there’s now slowly more research that proves there is evidence of that.

Representing the political establishment Norman Lamb, the Liberal Democrat MP for North Norfolk and chair of the Science and Technology Select Committee, called on Theresa May to legalise cannabis, particularly in the wake of recent news stories about how children like Alfie Dingley and Billy Caldwell, who suffer from seizures, could benefit from using cannabis-based medicine.

Norman Lamb MP spoke on the significance of recent cases, the importance of medicinal legalisation and the potential for full legalisation: I’ve always said that you have to get medicinal use legalised first, and I think last week was a very significant moment because it was the first time a government has reacted by saying: We’re reviewing it. That’s not nearly enough, and we need to keep pushing them constantly to go the whole way, but that was a big breakthrough for this government to do that, and it was because children’s lives were seen to be at risk. They thought: There’s political embarrassment here. If we can get medicinal use legalised, just as has happened now in the majority of US states, then you can have a rational debate about full legalisation, which I strongly support.

UK Rapper, documentary maker and activist Professor Green (AKA Stephen Manderson) brought his passion and insight to the panel following his critically acclaimed BBC documentary on the subject, Is It Time to Legalise Weed?

Professor Green&#a0;spoke on British attitudes to cannabis: I think it’s a generational thing, to be honest, and I donߣt think we have a very liberal attitude to much. What happens with that is you have a lack of education because things aren’t spoken about. We’re less liberal when it comes to many things when you compare us to other parts of the world, and what we get from that is many more problems. It doesn’t help anything, all it does it cause more problems. If somethingߣs underground, it’s not spoken about. It’s all the scaremongering in the media. How many times do you see cannabis psychosis in the newspapers?

Dr Frank D’Ambrosio delivered his expertise to the debate. As one of the USA’s leading voices for medicinal cannabis policy reform his knowledge of how successful medical marijuana has been in the US proved invaluable.

Dr Frank spoke on California’s experience with legalisation: California is doing just fine. I don’t think anybody needs to worry about California. We’ve had medical cannabis legalised since 1996, we passed the Compassionate Use Act, Proposition 15, Senate Bill 420. So for 20 years we’ve had patients getting access to medicine. Although the underground market still existed, people were using the dispensaries and they were able to get their medicine. Two years ago we voted for legalisation for the recreational end. Recreational only means intent. Just because youߣre intending to use the cannabis to achieve the psychoactive effect of the THC, doesn’t mean you’re not still getting the benefits. Even though it’s called recreational, you’re still getting the medical benefits.

Kate Rothwell, who started this petition via Change.org provided both a personal story and more systemic ask, calling for legalisation for medical use in the UK, and for it to be available on the NHS. Inspired by the experience of her 11-year-old cousin, Oliver, who has severe epilepsy that is alleviated by cannabis oil, she highlighted the predicament faced by many parents where doctors are forced to withdraw medical help on the NHS if patients are using cannabis oil. Leaving families having to choose between medical care or an increase in seizures.

Kate Rothwell spoke on her cousin Oliver and the family situation which inspired her to start her petition: About 18 months ago, my aunt and uncle spoke to the hospital who said: You can try cannabis oil. We’re not allowed to prescribe that because obviously it’s not legal as a medication here. They bought it online and were delivering it at home, a couple of drops, and the symptoms dropped massively. He was having 20 seizures a day and that dropped down to just a handful, which was completely lifechanging for him and for our whole family, really. About a month ago, the doctors turned around and said: We’re really sorry, we thought it was going to become legal sooner than this and our hands are completely tied. You’re going to have to stop giving him the medication. They had to, because the NHS couldnߣt give them any other medication if he was still on cannabis oil. He came off it, and within 48 hours he had a drop seizure and knocked out his teeth. He’s been having really severe seizures ever since. It’s absolutely devastating, and none of us really knew what to do.

The symposium can be viewed in full on NME.com Friday 29th June 2018.

SMOKER’S CLUB FESTIVAL

The Smoker’s Club Festival experience is more of a paradise than a membership. Tailored entirely for the Californian smoker culture, everything from the lineup to the food proves that. With some legendary performances from headliners such as Wiz Khalifa and Kid Cudi, this event is impossible to pass up even for the average concert goer. The diverse arrangement of artists shows that these people know their crowd and every type of sound they love. There’s something for everyone with artists like Mac Miller, Lil Skies, and Dom Kennedy. Based in the hip-hop heavy area of Long Beach every artist that comes through shows love to the OG’s such as Snoop Dogg and the new comers like Vince Staples. Even if you don’t take part in the smoking activities some artists will even share from their supply as well. As someone that went alone I found the crowd and it’s people to be extremely friendly as far as festivals go. They all came for a good experience with some of their favorite artists playing classics and older mixtapes. The buzz for this festival grew the moment the line-up was announced and I’m sure many are impatiently waiting to see what they have up their sleeve for next time.

 

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