Posts tagged with "Belfast"

Endothelial progenitor cells for treating stroke patients

A new study recently published in STEM CELLS Translational Medicine demonstrates the long-term safety of laboratory-expanded endothelial progenitor cells for treating ischemic stroke. This could be good news for the 15 million people who, according to to the World Stroke Organization, suffer from this dangerous condition each year.

Ischemic stroke is the most common type of stroke, affecting nearly 90 percent of all cases. It is caused by a blocked blood vessel in the brain. In the normal central nervous system, endothelial progenitor cells (EPCs) play an active role in building blood vessels. This has led researchers to wonder whether EPCs circulating in the blood could be recruited after a stroke to assist in repairing damaged vessels in the brain. However, there is one major problem with this idea: The number of circulating EPCs is too low to provide much regenerative capacity – a number that further decreases in the aging or in those with heart problems.

This makes ex vivo (lab) expanded EPCs an attractive alternative.

“Transplantation of EPCs was already determined in animal experiments to be a safe and effective method for treating ischemic stroke. However, their safety and efficacy had yet to be determined in humans,” said Zhenzhou Chen, M.D., Ph.D., Southern Medical University, Guangzhou, China, and a corresponding author on the study. “In our trial, we tested the safety and feasibility of transplanting an acute ischemic stroke patient with his or her own (autologous) ex vivo expanded EPCs.”

Eighteen patients were recruited for the randomized, single-blinded study. Each received conventional treatment after their stroke then, seven days after symptom onset, underwent a bone marrow aspiration to collect EPCs and bone marrow stromal cells (BMSCs) for expansion in the lab. The patients were divided into three groups and, beginning at week four after the aspiration, one group was intravenously infused with their own EPCs, while the other two groups received either their own BMSCs or a saline placebo as the controls.

Each patient was then monitored for 48 months. Study co-author Xiaodan Jiang, M.D., Ph.D., also from Southern Medical University, explained, “We watched for mortality of any cause, adverse events and any new-onset diseases or conditions. Changes in neurological deficits were also assessed at different time points.”

In the end the researchers found no toxicity events nor did they see any infusional or allergic reactions in any of the patients. “The EPC group had less serious adverse events compared to the placebo-controlled group, although there were no statistical differences in mortality among the three groups,” Dr. Chen reported. “Ex vivoexpansion always raises concerns that it may cause instability in the chromosomes or maybe lead to tumors. However, in our long-term study we observed no increased tumorigenicity. This safety indicator was also confirmed by many animal studies and other trials using expanded bone marrow-derived stem cells for treatment of ischemic stroke.”

The researchers did note limitations in their study, including lack of patient-centered quality of life outcomes. “Moreover, because of the small size of the cohorts involved, we could neither identify the neurological or functional benefits of EPCs on ischemic stroke, nor determine the pros and cons between EPCs and BMSCs for stroke treatment,” Dr. Jiang said. “Thus, we believe a larger phase 2 trial is warranted.”

“This is a promising line of cell therapy research using a novel treatment method that is simple and non-invasive,” said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. “We look forward to larger phase 2 trial results.”

The full article, “Autologous endothelial progenitor cells transplantation for acute ischemic stroke: A four-year follow-up study,” can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices. SCTM is the official journal partner of Regenerative Medicine Foundation.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (www.StemCells.com), celebrating its 36th year, is the world’s first journal devoted to this fast paced field of research. The Oncologist® (www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 23rd year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

About Wiley: Wiley, a global company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical and scholarly journals, combined with our digital learning, assessment and certification solutions, help universities, learned societies, businesses, governments and individuals increase the academic and professional impact of their work. For more than 200 years, we have delivered consistent performance to our stakeholders. The company’s website can be accessed at www.wiley.com.

About Regenerative Medicine Foundation (RMF): The non-profit Regenerative Medicine Foundation fosters strategic collaborations to accelerate the development of regenerative medicine to improve health and deliver cures. RMF pursues its mission by producing its flagship World Stem Cell Summit, honouring leaders through the Stem Cell and Regenerative Medicine Action Awards, and promoting educational initiatives.

Picture This

PICTURE THIS RELEASE NEW SUMMER ANTHEM “WHEN WE WERE YOUNG” TODAY
MORE NEW MUSIC COMING SOON
LISTEN HERE: https://republic.lnk.to/WWWYPR
WATCH LYRIC VIDEO HERE: http://vevo.ly/6iDiru
NEW YORK, NY (June 15, 2018) – Picture This share a new summer anthem entitled“When We Were Young” today. Get it HERE via Republic Records. The band released an official lyric video for the song as well today, watch HERE.
“When We Were Young,” is a new song from the guys upcoming second full length studio album —due out soon.

The biggest act in Ireland and the nation’s hottest musical export in decades, Picture This— Ryan Hennessy [singer], Jimmy Rainsford [drums], Owen Cardiff [guitars], and Cliff Deane [bass] — arrived as a phenomenon with their self-titled 2017 full-length debut. Certified triple-platinum in Ireland, it held the #1 spot Overall in the country for four weeks, while topping the Streaming Chart for seven weeks. Moreover, it’s remained in the Top 5 since release—only bested by Ed Sheeran’s Divide last year. Two years since their formation, they’ve impressively sold over 300K tickets, concluding 2017 with a sold-out UK and Ireland tour highlighted by gigs at O2 Shepherd’s Bush London, SSE Arena Belfast, and a two-night stand at 3Arena in Dublin. The band recently received the Album Of The Year award at the 2018 Irish Post Music Awards. This summer marks their first stadium tour in Ireland with RDS stadium on June 23 already sold out.

FOR MORE INFORMATION ON PICTURE THIS
Bryan Kehn

Bryan.Kehn@umusic.com

ABOUT REPUBLIC RECORDS
A division of Universal Music Group, the world’s leading music company, Republic Records is home to an all-star roster of multi-platinum, award-winning legends and superstar artists such as Ariana Grande, Aminé, Black Sabbath, DNCE, Florence + the Machine, Gotye, Hailee Steinfeld, James Blake, James Bay, John Mellencamp, Jordan Smith, Julia Michaels, Keith Richards, Kid Cudi, Liam Payne, Marian Hill, Of Monsters and Men, Post Malone, Seth MacFarlane, Stevie Wonder, and more. Founded by brothers and chief executives Monte and Avery Lipman, it is also comprised of innovative business ventures, including American Recordings (The Avett Brothers, Towkio), Boominati Worldwide (Metro Boomin), Brushfire (Jack Johnson), Casablanca Records (Giorgio Moroder, KUNGS, Tïesto), Cash Money (Drake, Lil Wayne, Nicki Minaj), Hollywood Records (Sofia Carson, Zendaya), Lava Records (Greta Van Fleet, Jessie J, Lorde), Monkeywrench (Pearl Jam), XO (Belly, The Weeknd), Roc Nation (Jaden Smith, Justine Skye, The Dream), among others. Republic also maintains a long-standing strategic alliance with country powerhouse Big Machine Records (Taylor Swift), and Universal Music Latin Entertainment (Luis Fonsi, J Balvin). In addition, Republic has expanded to release high-profile soundtracks for Universal Pictures (Fifty Shades of Grey, SING), Fox TV (Lee Daniels’ STAR), and NBC TV (The Voice), as well as other notable film and television franchises.

Snow Patrol Debut MV

Snow Patrol Debut Music Video for “Soon” confirms North American tour with Ed Sheeran &Headlining dates throughout the U.K. & Ireland. First Album in seven years Wilderness out now via Republic/Polydor Records.

“….a fantastically ambitious collection of songs, one more direct and intimate than many previous Snow Patrol offerings…“Wildness” signals a triumphant Snow Patrol return.” -Associated Press

This morning, Snow Patrol debut the music video for their song “Soon,” from their album Wildness. Directed by Brett Simon, who has helmed videos for every track on the album, ‘Soon’ is a poignant snapshot of Gary Lightbody and his father, who is suffering from dementia. Lightbody revealed: “Soon’ is about my dad. Three years ago he was diagnosed with dementia. I wanted to write a song that connected us both and let him know I was with him and would be always. The video we made for this (directed by Brett Simon) is me and my dad sitting together watching old home movies. Filming it with him was one of the best days I ever spent with my dad and I’m so grateful he got to share in the day and spend some time in my world. It meant everything to me.” Watch the video for “Soon” here. For more information about how music and technology can improve the lives of the elderly suffering from dementia and Alzheimer’s, visit Music & Memory here.

Recently, Snow Patrol have confirmed 8 headlining dates in the UK and Ireland throughout December and January. The band will perform in cities including Dublin, London, and Belfast (full dates below), and tickets will go on sale on Friday, June 8th at 9am Local Time here. Snow Patrol has also confirmed that they will support Ed Sheeran on 24 North American stadium dates, which will kick off at Pasadena’s Rose Bowl on Saturday August 18th. The tour will stop in cities including Seattle, Atlanta, Chicago, and Dallas (full dates below), and tickets for all dates are on sale now and available here.

Snow Patrol’s album Wildness, their first album in seven years, is out now and available for purchase on all formats here. To celebrate the release of Wildness, Snow Patrol debuted new music videos for “A Youth Written In Fire,” “Life and Death,” “Wild Horses,” and “A Dark Switch.” The band has previously released music videos for “Empress” “What If This Is All The Love You Ever Get?,” “Life On Earth,” and “Don’t Give In,” and you can watch them all here. Additionally, Ed Sheeran showed his support in an Instagram video here.

Snow Patrol recently returned to “Later… With Jools Holland” where they debuted a live rendition of “Empress,” along with performances of “Life On Earth,” “Heal Me,” and “Chasing Cars.” Snow Patrol also appeared as musical guests on The Late Show with Stephen Colbert on April 19th and The Late Late Show With James Corden on April 24th and performed “Don’t Give In,” the first single from the album.

Snow Patrol has launched a Spotify playlister website where fans around the world can create their own playlist of Snow Patrol songs throughout the band’s catalogue and share these playlists with a friend. When sharing the playlist, the fan marks his/her location as well as the recipient’s location on a global map. Check it out and create your own playlist at http://playlist.snowpatrol.com
Since their 1998 debut, Songs for Polarbears, Snow Patrol has racked up an impressive number of critical and commercial accolades, including 15 million global album sales, 1+ billion global track streams, five UK Platinum Albums, and are Grammy, BRIT Award and Mercury Music Prize nominated. After their Fallen Empires tour ended in 2012, band members —which also include multi-instrumentalist Johnny McDaid, guitarist Nathan Connolly, bassist Paul Wilson, and drummer Jonny Quinn — decided to take a step back from the band, and focus on their own projects. Gary Lightbody continued his work with his Tired Pony side project with members of Belle and Sebastian, R.E.M, Reindeer Section and Fresh Young Fellows and moved to Los Angeles to begin writing songs for movies (including “This Is How You Walk On” for 2017’s Gifted), and doing a number of high-profile co-writes with Ed Sheeran, Taylor Swift, Biffy Clyro, and One Direction. Taking this extended break from Snow Patrol proved to be a source of inspiration, and writing songs that were not pulled directly from his own psyche helped heal what Lightbody considered to be not so much writer’s block as life block.

Wildness Track Listing
01 Life On Earth
02 Don’t Give In
03 Heal Me
04 Empress
05 A Dark Switch
06 What If This Is All The Love You Ever Get?
07 A Youth Written In Fire
08 Soon
09 Wild Horses
10 Life And Death

Snow Patrol North American Tour Dates With Ed Sheeran
Aug18 /// Pasadena, CA /// Rosebowl
Aug 21 /// San Francisco, CA /// AT&T Park
Aug 25 /// Seattle, WA /// CenturyLink Field
Aug 30 /// Toronto, ON /// Rogers Centre
Aug 31 /// Toronto, ON /// Rogers Centre
Sep 6 /// St. Louis, MO /// Busch Stadium
Sep 8 /// Detroit, MI /// Ford Field
Sep 21 /// East Rutherford, NJ /// MetLife Stadium
Sep 22 /// East Rutherford, NJ /// MetLife Stadium
Sep 27 /// Philadelphia, PA /// Lincoln Financial Field
Sep 29 /// Pittsburgh, PA /// PNC Park
Oct 4 /// Chicago, IL /// Soldier Field
Oct 6 /// Nashville, TN /// Nissan Stadium
Oct 13 /// Kansas City, MO /// Arrowhead Stadium
Oct 17 /// Fargo, ND /// Fargodome
Oct 20 /// Minneapolis, MN /// US Bank Stadium
Oct 23 /// Milwaukee, WI /// Miller Park
Oct 27 /// Dallas, TX /// AT&T Stadium
Oct 31 /// New Orleans, LA /// Mercedes-Benz Stadium Superdome
Nov 3 /// Houston, TX /// Minute Maid Park
Nov 7 /// Tampa, FL /// Raymond James Stadium
Nov 10 /// Atlanta, GA /// Mercedes-Benz Stadium

Snow Patrol Headlining European Tour Dates
Dec 5 /// Newcastle, England /// Metro Radio Arena
Dec 7 /// Belfast, Northern Ireland /// The SSE Arena
Dec 11 /// Dublin, Ireland /// 3Arena
Jan 25 /// Birmingham, England /// Birmingham Arena
Jan 26 /// London, England /// O2 Arena
Jan 29 /// Leeds, England /// First Direct Arena
Jan 30 /// Manchester, England /// Manchester Arena
Jan 31 /// Glasgow, England /// The SSE Hydro
*w/ Ed Sheeran
www.snowpatrol.com
www.facebook.com/snowpatrol
www.instagram.com/snowpatrol
www.twitter.com/snowpatrol
www.youtube.com/snowpatrol

FOR MORE INFORMATION ON SNOW PATROL
Taylor Vaughn
Taylor.Vaughn@umusic.com

Mary Moyer
mary@qprime.com

Emilio Herce
emilio@qprime.com

ABOUT REPUBLIC RECORDS
A division of Universal Music Group, the world’s leading music company, Republic Records is home to an all-star roster of multi-platinum, award-winning legends and superstar artists such as Ariana Grande, Aminé, Black Sabbath, DNCE, Florence + the Machine, Gotye, Hailee Steinfeld, James Blake, James Bay, John Mellencamp, Jordan Smith, Julia Michaels, Keith Richards, Kid Cudi, Liam Payne, Marian Hill, Of Monsters and Men, Post Malone, Seth MacFarlane, Stevie Wonder, and more. Founded by brothers and chief executives Monte and Avery Lipman, it is also comprised of innovative business ventures, including American Recordings (The Avett Brothers, Towkio), Boominati Worldwide (Metro Boomin), Brushfire (Jack Johnson), Casablanca Records (Giorgio Moroder, KUNGS, Tïesto), Cash Money (Drake, Lil Wayne, Nicki Minaj), Hollywood Records (Sofia Carson, Zendaya), Lava Records (Greta Van Fleet, Jessie J, Lorde), Monkeywrench (Pearl Jam), XO (Belly, The Weeknd), Roc Nation (Jaden Smith, Justine Skye, The Dream), among others. Republic also maintains a long-standing strategic alliance with country powerhouse Big Machine Records (Taylor Swift), and Universal Music Latin Entertainment (Luis Fonsi, J Balvin). In addition, Republic has expanded to release high-profile soundtracks for Universal Pictures (Fifty Shades of Grey, SING), Fox TV (Lee Daniels’ STAR), and NBC TV (The Voice), as well as other notable film and television franchises.

Guinness x St. Patrick’s Day

200 Years of Friendship and St. Patrick’s Days : In Time for Milestone St. Patrick’s Day, Guinness is donating $1 to charity for each adult that dons a ‘Stache

This year marks the  200th St. Patrick’s Day Guinness will share with America, the latest reminder of the two-century connection between a legendary brewery and its good friends across the Atlantic. Once again, in the days and weeks leading up to March 17, it’s time for us all to embrace the stories we tell,  the memories we make and the bonds we build over a pint of Guinness.

The Guinness brand is encouraging all Americans, 21 years and older, to make a simple pledge (assuming they’ve already promised to drink responsibly, of course): gather with friends, new or old, toast to the many things we all have in common…and give a ‘Stache. Indeed, this St. Patrick’s Day, the Guinness ‘Stache – that unmistakable hint of foam left behind on the upper lip after the first sip of stout – is back as a symbol of the goodness and the Irish-ness that lives within all of us.

 From now through March 31, 2018, when adult beer lovers share photos of their ‘Staches – self-grown and groomed, drawn-on, or Guinness-enhanced – on social media (tagging @GuinnessUS and using #StacheForCharity), Guinness will donate $1 (up to $100,000) to the Guinness Gives Back Fund*, which supports nonprofits that contribute to the common good in our communities, including Team Rubicon, a veteran-led disaster response organization.

“Over the past 200 years, so much has changed – yet so much has stayed the same, like people coming together to raise a pint of Guinness with their friends on St. Patrick’s Day,” said Guinness Brand Director Emma Giles. “We are proud to be part of such an enduring tradition that celebrates Irish heritage and, when it comes down to it, the power of friendship. The Guinness ‘Stache is a great way to bring that to life in a fun way for a great cause.”

The symbol of the ‘Stache will appear alongside Guinness brand activity at bars and restaurants and on social media throughout the St. Patrick’s Day season, including in some digital content that pays homage to 200 years of mustaches in America. To spread the word about the bonds a ‘Stache can build, the brand is releasing additional digital content that will help us all reflect on the friendships we cherish – and some very recognizable Guinness fans will also get involved in spreading the word.

In addition, it’s time for the latest limited-edition Guinness Draught cans, which will hit shelves in time for St. Patrick’s Day. The ongoing series celebrates the famed Guinness ad campaigns of the 1930s and ‘50s. While it doesn’t have a mustache, the kinkajou – which we thought was a sloth at first – will be featured on this version.

To keep an eye on everything the Guinness brand is doing and to get in on the ‘Stache action, follow @GuinnessUS on Twitter, Instagram and Facebook.

Whether you’re making a new friend or meeting an old one, having a Guinness Draught, or ordering up any other Guinness beer this St. Patrick’s Day, please respect the beer and drink responsibly.

beer

*The Guinness Gives Back Fund is a corporate donor advised fund administered by Fairfield County’s Community Foundation. The Fund’s mission is to support local charitable organizations which are classified under Section 501(c)(3) of the Internal Revenue Code that are aligned with the corporate focus areas of Diageo North America, Inc.

 

Media Contacts:

 

Dave Finn, Taylor

(212) 714-5792 

dfinn@taylorstrategy.com

 

Jim Sias, Diageo

(646) 223-2305

jim.sias@diageo.com