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MOTS-c Peptide: Insulin Resistance Research

Studies suggest that peptides are amino acid chains that may serve important roles in various biological activities. Recently, mitochondrial ORF of the 12S rRNA type-c (MOTS-c) peptide has emerged as a promising compound in mitochondrial research.

The mitochondrial genome encodes a peptide that controls nuclear gene expression in the mitochondria in reaction to conditions like metabolic stress. It has suggested promise in anti-aging, anti-inflammatory, and metabolic studies in the laboratory. However, further study is required to understand the potential of MOTS-c fully.

The potential properties of MOTS-c peptide for sale, including improved muscular function, reduced insulin resistance, reduced inflammation, improved bone health, and improved metabolic and cardiovascular health, will be discussed.

Overview of the MOTS-c Peptide

The MOTS-c peptide is naturally produced. It is found in the energy-generating organelles of cells called mitochondria. The peptide has the amino acid sequence H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH, and it is 16 amino acids in length.

Early studies examined its possible relevance in the context of research in age-related conditions such as diabetes, cardiovascular disease, osteoporosis, postmenopausal obesity, and Alzheimer’s disease. Studies suggest that “under stress circumstances, MOTS-c translocates to the nucleus where it controls a wide range of genes in response to metabolic dysfunction.”

MOTS-c Peptide and Insulin Resistance

The prospect of MOTS-c in insulin resistance and metabolic studies are among its most actively studied potential properties. In metabolic diseases like insulin resistance, improving glucose metabolism in skeletal muscles has been suggested by many animal studies. Skeletal muscle glucose uptake may be increased, and visceral fat levels may be reduced as a result of this method of action, research suggests.

Activation of the AMPK pathway has been speculated to occur due to MOTS-c’s selective targeting of skeletal muscle and its inhibition of the folate cycle and its attached de novo purine production. Thus, it seemed that MOTS-c in mice may have prevented insulin resistance and diet-induced obesity caused by both aging and a high-fat diet.

In addition to its potential properties for cardiovascular health, MOTS-c has been suggested to increase thermogenesis in adipose tissue and promote the “browning” of white (beige) fat. The ERK signaling pathway is thought to be the mediator of MOTS-c’s actions.

Studies in gestational diabetes, a kind of diabetes caused by increased insulin resistance during pregnancy, have also purported that MOTS-c may be relevant. Findings suggest that hyperglycemia appeared dramatically decreased, insulin sensitivity and glucose tolerance seemed enhanced, and birth weight and the risk of neonatal mortality were reduced in a mouse subject of type 2 diabetes when MOTS-c was given daily during pregnancy.

MOTS-c seems to have an impact on skeletal muscles beyond only enhancing glucose absorption. The peptide may also affect muscle atrophy associated with obesity and type 2 diabetes, as suggested by findings from animal studies. In mice, MOTS-c seems to work by lowering plasma myostatin levels and increasing AKT phosphorylation, both of which suppress the activity of the muscle-wasting gene transcription factor FOXO1. Research suggests that dystrophic muscle atrophy may also be mitigated, especially in models of Duchenne muscular dystrophy (DMD).

MOTS-c Peptide and Cardiovascular Function

It has been hypothesized that MOTS-c peptides may have a protective impact on the heart muscle owing to increased mitochondria activity in the myocytes. One research study suggested that the peptide may have improved cardiac function and reduced inflammation in a mouse model of heart failure. The peptide seemed to increase antioxidant capacity in the hearts of mice, decrease cell apoptosis, and activate the AMPK pathway.

Studies in diabetic rats suggested that presentation of the peptide appeared to have enhanced myocardial mitochondrial impairment, maintained cardiac systolic and diastolic function, and modified 47 disease-causing genes related to apoptosis, immunoregulation, angiogenesis, and fatty acid metabolism, suggesting that MOTS-c may also help reduce the detrimental impact of type 2 diabetes on the heart.

Thanks to activating the AMPK and the anti-oxidative activities of the peptide, animal studies also suggest it may support the decrease of inflammation in the heart and shield against vascular calcification (VC), which is a consequence of atherosclerosis.

Heart systolic function, mechanical heart efficiency, and diastolic function are all hypothesized to be enhanced by MOTS-c in mice. These findings purport that MOTS-c may enhance the cardiovascular advantages of exercise. Researchers have speculated that stimulating the NRG1-ErbB4-C/EBP pathway may have comparable effects on cardiac function as exercise.

MOTS-c Peptide and Bone

Investigations purport that MOTS-c may improve bone health via its proposed potential to activate phosphorylated AMPK. One research suggests that in a mouse model of osteoporosis, MOTS-c peptide appears to dramatically block osteoclast development and minimize bone loss, as measured by micro-CT examination. As a result of their research, the team speculated that “MOTS-c may wield as a blocker of osteoporosis condition via AMPK dependent inhibition of osteoclastogenesis.”

In another study, researchers hypothesized that ultra-high molecular weight polyethylene particle-induced osteolysis in an animal model appeared to have resulted in less bone loss and inflammation. Osteoclastogenesis seemed to be suppressed by MOTS-c because it may have increased the osteoprotegerin to receptor activator of nuclear factor kappa B ligand ratio in osteocytes.

References

[i] Ming W, Lu G, Xin S, Huanyu L, Yinghao J, Xiaoying L, Chengming X, Banjun R, Li W, Zifan L. Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation. Biochem Biophys Res Commun. 2016 Aug 5;476(4):412-419. doi: 10.1016/j.bbrc.2016.05.135. Epub 2016 May 26. PMID: 27237975.

[ii] Lee C, Kim KH, Cohen P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016 Nov;100:182-187. doi: 10.1016/j.freeradbiomed.2016.05.015. Epub 2016 May 20. PMID: 27216708; PMCID: PMC5116416.

[iii] Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009. PMID: 25738459; PMCID: PMC4350682.

[iv] Lu H, Tang S, Xue C, Liu Y, Wang J, Zhang W, Luo W, Chen J. Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation. Int J Mol Sci. 2019 May 17;20(10):2456. doi: 10.3390/ijms20102456. PMID: 31109005; PMCID: PMC6567243.

[v] Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X. The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus. Pharmacol Res. 2022 Jan;175:105987. doi: 10.1016/j.phrs.2021.105987. Epub 2021 Nov 17. PMID: 34798268.

HARRY POTTER + REEBOK

Reebok just announced its latest collaboration with Warner Bros: Harry Potter x Reebok. The full-family collection includes four pairs of adult footwear, each of which represents pivotal moments from Harry’s time at Hogwarts. Paired with the footwear is a range of adult, collegiate-style apparel as well kids Club C’s and Classic Leathers.

Accompanying the collection is campaign imagery that was shot in the UK and gives off a very cool, UK student energy (see sneak peek below).

The product will be launching on Reebok.com and Amazon.com on 12/1.

Reebok just announced its latest collaboration with Warner Bros: Harry Potter x Reebok via 360 MAGAZINE.

The Other Grand Prix

Race week in Las Vegas kicked off with four Formula 1 drivers piloting out-of-this-world vehicles in a series of three challenges in the Nevada desert. The fourth episode of the (Un)serious Race Series saw the quartet of F1 World Champion Max Verstappen and Oracle Red Bull Racing teammate Sergio “Checo” Pérez and Scuderia AlphaTauri aces Yuki Tsunoda and Daniel Ricciardo face off in two-seater hovercrafts. The isolated site is well known for a different type of hovering vehicles – alien spacecraft – so F1 drivers racing hovercrafts, highly unusual anywhere else, was par for the course.

While it was a friendly competition, the competitive nature of the drivers shone through, leading to strategy discussions between teammates and on-track game faces appearing between the near-constant laughter. The 13-foot long, 26.5 horsepower hovercraft tested the drivers’ skills as they provided little traction and relied on counter steering to glide through the course at a top speed of 30 mph/48 kph. Dry desert wind and ample dust only added to the skill needed to tackle the unique challenge.

Daniel and Yuki, who were pitted against each other in the mini jet boats in Miami, proved a formidable hovercraft team, and while Max and Checo won the first challenge and put up a solid fight to the end, the Scuderia AlphaTauri drivers were able to eke out the overall win by a 2-1 challenge tally. But there was nothing but smiles from all four drivers as the trophy was awarded against a crashed flying saucer not far away.

“It’s fun to be out here in the desert ahead of the Las Vegas GP. I think the hovercrafts look really cool and they were really fun to drive. They were slower than I thought they would be, but I suppose you’re floating over the ground. The challenges are fun, especially when you get to do it together as a team with Checo, also with Scuderia AlphaTauri. This series has been fun this year, we’ve driven lots of different vehicles all over the world, I think that makes it beautiful,” said Max.

Regarding the hovercrafts, Checo commented, “I’ve seen them, but I’ve never driven a hovercraft before, so it’s my first time…and I ended up eating a lot of sand, so I don’t need lunch for today. They collapse and go into the floor when you unbalance them, so it was quite challenging – you have to think a lot while driving them.” Of the upcoming Las Vegas race, he said, “I think Las Vegas is a unique venue – with the fans, the racing at night for the first time here – I think people are really going to enjoy it.”

“I definitely enjoy doing these things,” said Ricciardo. “On a race week we have the race and that’s our primary focus, and on track everything’s so competitive, so to spend some time with not only Yuki, but Max and Checo and to be out here in the desert in an environment where we’re all just having a laugh – these are probably the best workdays we can get.”

“I didn’t know how the vehicles behave,” said Tsunoda. “It’s actually a lot of fun, lots of drifting, but at the same time you have to control the throttle precisely to make it turn quickly. If you release too much throttle and touch too much ground, you stop. So, there’s fine tuning and that makes it difficult, but overall, it’s really, really fun.”

Here’s how it all unfolded:

Challenge 1: “Rescue Mission” – Max and Checo are victorious.

The teams took turns embarking on a tandem sprint through a course laden with obstacles in pursuit of a lockbox at the end of the course. Their mission: recover the lockbox, execute a driver switch and race back to the starting point. Victory belonged to the team that accomplished this rescue and return mission with utmost speed and finesse.

Challenge 2: “Crop Circles” – Daniel and Yuki make a comeback and earn the win.

Each driver was given 30 seconds to complete as many “crop circles” as possible around the pillars, creating crop circles in the process. Victory would go to the team that completed the most donuts/circles. In an unexpected and humorous move, Max attempted to get a “leg up” on the competition by hanging out of the hovercraft and using his left foot to assist in completing tighter and faster donuts. Unfortunately, the out-of-the box strategy was not enough to take the win.

Challenge 3: “The Final Race” – Daniel and Yuki are the winners!

With each team having a win under their belt, they put all the chips on the table for the relay tie breaker. In a head-to-head race, the teams made their way through a slalom course one driver at a time, switching drivers for the second lap. Daniel banked turn after turn before booking it down the straight with Max just milliseconds behind him before Yuki and Checo jumped into the vehicles. In the end, Yuki was able to pull ahead and float across the finish line to secure the overall victory.

The fourth (Un)series Race Series unfolded in typical lighthearted and tongue-in-cheek style. Through the year, the friendly – but ultimately somewhat competitive – series kept the drivers on their toes and challenged them in unfamiliar vehicles and terrain: from the waterways of Miami in mini jet boats, to the Erzberg iron mine of Austria in 500 horsepower mega trucks, from Kei trucks in a Japanese-style gameshow to Renegade Hovercrafts in the Nevada desert.

Watch Scuderia AlphaTauri and Oracle Red Bull Racing in hovercrafts HERE. A newscut, social newscut and rights free imagery are available on Red Bull Content Pool HERE.

CHIP ZDARSKY SHARES DARK SECRETS

Earlier today, retailers were invited to the Avengers: Twilight Retailer Conference to learn more about AVENGERS: TWILIGHT straight from the source! Series writer Chip Zdarsky and Marvel Comics VP Executive Editor Tom Brevoort teased the upcoming saga’s biggest mysteries, discussed the series’ scope and impact, and answered retailer questions. Hosted by Ryan Penagos (VP & Creative Executive at Marvel), attendees also got an exclusive look at never-before-seen covers along with interior artwork and design sheets from series artist Daniel Acuña. Right now, fans are welcome to check out some of what was unveiled in anticipation of the debut issue hitting stands on January 10!

In AVENGERS: TWILIGHT, readers will leave the Marvel Universe they know behind as they follow an aged Steve Rogers through a dark future where the Avengers’ dream has been twisted into a nightmare! Along the way, Zdarsky and Acuña will introduce a fascinating new cast of characters, including future versions of familiar faces as well as future Avengers members who have startling connections to the heroes of today. Instead of protecting the world, the new Avengers of AVENGERS: TWILIGHT use their power and influence to control it, driving Steve to come out of retirement to end their rule and restore the Avengers’ legacy to its former glory, but even after assembling the few friends he has left, Captain America will be hopelessly outmatched by the system the Avengers’ ruthless successors built. This bold and thought-provoking saga that tackles the very nature of being a super hero will also slowly peel back the layers of a shadowy history, exposing the shocking events that caused Earth’s Mightiest Heroes to fall so far…

“My goal with anything is to create a story that is both new reader friendly and also welcomes in older readers who will enjoy the references sprinkled throughout,” Zdarsky explained on the call. “I think if you have a base knowledge of Marvel super heroes, there’s really something for you here. And getting a chance to do something that’s self-contained in six issues with one consistent artist throughout is my favorite kind of project because those are types of books you can sell forever.”

Get a new glimpse into this corrupted vision of Marvel’s tomorrow, including design sheets for Cap’s new allies and enemies and a first look at the series’ new look for Thor in the issue #4 covers. Stay tuned for more AVENGERS TWILIGHT news and preorder issue #1 at your local comic shop today! For more information, visit Marvel.com.

Absolutely Cerebrum

After building up buzz with widespread tastemaker praise around the globe, acclaimed U.K. singer, songwriter, and performer Absolutely proudly presents her anxiously awaited debut album Cerebrum out now via Epic Records.

Listen HERE and view the trailer HERE

Living up to its title, Cerebrum beckons listeners down a rabbit hole and straight into Absolutely’s multi-dimensional world. Each of the record’s 13 tracks corresponds to a different “room” or chamber of her mind. It opens with Daylight where ethereal hums peek through distorted synths. As momentum builds, she issues an ultimatum on the refrain, “Baby I just need you here, it’s now or never.” Then, there’s Arrivals. She uncorks a flurry of emotions over warbling production. Holding nothing back, she wonders aloud, “How much love can I hold?” Expanding this vision, Glass hinge on an otherworldly guitar riff punctuated by head-nodding 808s and hi-hats. Fittingly, the journey concludes with Window. As if letting in a rejuvenating burst of energy, she urges, “Take a breather baby, open up a window. See the full track listing below.

The album also launched with a beautiful cover story in collaboration with The Luna Collective for a special-edition zine that will take fans into the world of Cerebrum. View the cover HERE

She paved the way for the album with Close To You and MIA. The latter has received acclaim from the likes of NYLON who praised, “There’s a strong melodic backbone that she adorns with her own quirks, scuzzying it up with contrasting textures while her silky voice flies free.”

MIA followed Symphony, which dropped this summer and claimed real estate on Spotify playlists such as “New Pop Picks” and more. Earning acclaim, she sat down for an interview with EUPHORIA. The outlet praised her as, “a young powerhouse who has been taking the industry by storm behind the scenes,” before noting, “Ready to receive her own bouquet of flowers, Absolutely has been feeding the world with her own music, and boy, what a promising artist she is already!”

She continues to serve up scorching anthems. A prior release, Stranger Phase, landed a coveted spot on the Spotify New Pop Picks playlist and earned critical acclaim from NYLON. FIZZY MAG professed, “This girl’s creativity knows no bounds, and she’s taking us on a wild journey through her world of music.” At the same time, Fever Dream has just begun to pick up steam, and its predecessor, Patterns, has already cracked over 100K streams and counting. Introducing Absolutely, FLAUNT praised her debut single, Higher, raving, “The singer-songwriter from South London brings together a plethora of genres on “Higher.” From pop to R&B and electronic, the debut single has it all with the help of Dave Hamelin, the producer behind artists like Beyoncé and 070 Shake.” Watch HERE.

Absolutely is currently touring as direct support on Raye’s My 21st Century Blues Tour, captivating audiences and gaining new fans at each stop. Tickets are available now at rayeofficial.com.

Allow Absolutely to welcome you to Cerebrum now.

Cerebrum Tracklisting:

Daylight
Arrivals
24 Hours
Higher
MIA
Fever Dream
Close To You
Glass
Patterns
Speak Up
Stranger Phase
Symphony
Window

My 21st Century Blues World Tour 2023/24 Tour Dates w Absolutely

November 18 – Paris, France – La Cigale
November 19 – Amsterdam, Netherlands – Melkweg
November 20 – Esch-sur-Alzette, Luxembourg – Rockhal
November 21 – Amsterdam, Netherlands – Paradiso
November 23 – Berlin, Germany – Huxleys

November 24 – Warsaw, Poland – Progresja
November 26 – Copenhagen, Denmark – Vega
November 29 – Bridlington, UK – Bridlington Spa
November 30 – Glasgow, UK – O2 Academy

December 1 – Newcastle, UK – NX
December 2 – Manchester, UK – O2 Apollo
December 5 – Birmingham, UK – O2 Academy
December 7 – Bristol, UK – O2 Academy

Cotton Incorporated’s Blue Jeans Go Green™ Program

America Recycles Day on Nov. 15 reminds Americans the importance of promoting recycling, and Cotton Incorporated celebrates year-round by giving old denim a new purpose and circular life while keeping them out of landfills. Cotton’s Blue Jeans Go Green™ denim recycling program closes the loop on textile waste by reusing denim made from cotton and recycling well-loved pieces. Since the program’s inception in 2006, over 2,290 tons of denim have been diverted from landfills.

America Recycles Day is a Keep America Beautiful initiative that educates and encourages individuals on how to be more mindful of what they consume. Cotton Incorporated reminds consumers that textiles are recyclable, too. A sustainable wardrobe starts by always checking the label to understand what clothes are made of. If denim is made of at least 90% cotton, users can recycle it through Cotton’s Blue Jeans Go Green™ program.

“The Blue Jeans Go Green program™ does good for the Earth by avoiding the landfill and creating new possibilities for communities through their purpose,” Andrea Samber, director of brand partnerships for Cotton Incorporated, said. “Thanks to the renewability of denim made from cotton, your well-loved jeans, jackets, and more can be given a new life, from building insulation to pet bed inserts, thermal packaging and beyond. Recycling textiles is important every day, so we hope that America Recycles Day will be an opportunity for Americans to learn about this incredible program and understand how easy it is to get involved.”

Cotton Incorporated launched the Blue Jeans Go Green™ denim recycling program to encourage denim recycling, generate awareness for cotton sustainability, and create opportunities to make an impact in communities. With nearly 4,580,000 pieces of denim recycled through the program so far, Cotton Incorporated will continue to grow its ongoing commitment to recycling by reducing textile waste.

This America Recycles Day, Cotton Incorporated encourages consumers to join the commitment to recycling and wearing sustainable clothes, like denim made from cotton. Because every piece has potential, every piece can live longer, and every piece can be recycled. To learn more about Cotton Incorporated and the Blue Jeans Go Green™ Program, visit the website.

9 Style + Grooming Tips for Men

Looking your best is about feeling confident and comfortable in your own skin. While fashion trends come and go, there are some timeless tips for men’s grooming and style that stand the test of time. Follow these nine essential pointers to always put your best face forward.

1. Find a Great Hairstyle for Your Face Shape

Your hairstyle frames your face, so find one that complements your facial features. Oval faces can pull off almost anything, from short to long. Square faces look great with textured styles like fades or spiky hair. Round faces benefit from height on top with short sides. Heart-shaped faces suit voluminous quiffs or messy styles. An experienced barber like this one that’s been in Lansing for over ten years can recommend the most flattering cuts.

2. Moisturize Daily

Daily moisturizer is a must for every man. Look for light, oil-free formulas if you have oily or combination skin. Dry, flaky skin needs richer creams. Apply after washing or shaving when the skin is still damp to seal in moisture. Target areas that are prone to dryness like the T-zone on your nose, forehead and chin.

3. Don’t Neglect Your Skin Care Routine

Washing daily with a gentle cleanser removes dirt, oil and bacteria that can lead to breakouts. Exfoliate once or twice a week to slough off dead cells and keep pores clear. Use a daily SPF 30 sunscreen to prevent premature aging and skin cancer, even if you don’t think you’ll be outside much.

4. Keep Your Beard Neatly Trimmed

If you sport facial hair, regular trimming is essential for a polished look. Use clippers to maintain an even length, then tweezers to pluck stray hairs. Define the edges of your beard with shaving cream and a razor. Apply beard oil or balm daily to condition the hair and skin underneath.

5. Whiten Your Teeth

A bright smile with pearly white teeth gives your look an instant boost. Use whitening toothpaste and strips to reduce stains. If you drink coffee, tea, wine or smoke, brush after to prevent discoloration. See your dentist twice a year for cleanings and touch-up whitening treatments.

6. Tame Unruly Eyebrows

Your eyebrows frame your eyes, so keep them under control. Use small scissors or an electric trimmer to snip any hairs that extend beyond the natural shape. Don’t over-pluck from below or you may end up with thinner brows as you age. Just neaten up the top edges and underneath to keep things tidy.

7. Iron Wrinkled Clothes

Wrinkled clothes look sloppy no matter how nice they are. Invest in a good steam iron to smooth out wrinkles fast. Hang button-downs, pants and jackets immediately after ironing so they don’t re-wrinkle. For really stubborn wrinkles, use a spray bottle of water while ironing to help relax the fibers.

8. Practice Good Hygiene Daily

From bathing to dental care, don’t skip the basics. Shower daily using a germ-fighting body wash. Change into clean underwear and socks every day. Floss and brush twice daily. Deodorant is a must, along with regular hair washes and nail clipping. These simple habits make you look and feel fresher. If you’re also thinking how to stop itchy scalp, washing your hair regularly can help.

9. Drink Water and Eat Healthy Foods

What you put into your body shows on the outside too. Stay hydrated by drinking water throughout the day for clear, glowing skin. Eat plenty of fresh fruits, veggies, lean proteins and whole grains for a balanced diet. Avoid excessive alcohol, caffeine, processed foods and sugar to keep your overall health and appearance in top shape.

Following these essential grooming and style habits will have you looking like your best self every day. Find a routine that fits your lifestyle and stick to it. Invest time and care into your appearance, and your confidence will shine through.

How Can You Earn on Sports Betting?

It is believed that betting is a game of chance and luck. But, if played strategically, the probability of wins increases, and one can earn money.

Be it sport betting Zambia or America, you can rule the betting world. But how? So, check out some essential do’s and don’ts while placing a bet.

Essential Betting Tips

To minimize your losses and maximize profits, the most important is to think logically. You just can’t rely on the statistics and records. You need to use the presence of mind and some necessary tips that might turn the tables for you.

1. Learn About the Odds

Knowing the odds is quite essential. As they keep changing, one must be able to track them carefully and check the reasons behind them.

Odds not only tell you the probability of your win but also represent the profit you can earn on any bet you make.

Odds are mentioned in American, Decimal, or Fractional format. You must be able to read the odds before stepping into the betting world.

2. Go with the Best Betting Line

Knowledge of betting lines is equally important as that of odds. These might be different for a single bet on various sports. You should be able to decide the best one for you. The betting line could be a money line, a point spread, or a point total.

Firstly, you have to learn about all the betting lines, and then you need to use logic for which line will be more profitable at any given condition of betting.

3. Parlay Bets Could be Risky

Parlay are the cumulative bets that could earn you a large amount of money if you get lucky. But there is more risk involved in it. If looking for long-term betting, you better avoid such bets.

As in a parlay bet, you place more than one bet. But you earn only if you win all the included bets. In case you lose any of the single bets from it, you will lose all your money.

4. Manage Bankroll

Bankroll management is the most crucial point to be considered. Bankroll is the amount that you set for placing the bets. Always set a fixed limit, and never cross it. This will save you from the burden of losses.

Wins and losses go parallel in the betting game. If you know your limit, you will never face excess loss.

Bets usually go with the point system. For beginners, always bet 1% on 1 point. So, if your bankroll amount is $1500, your bet will be $15 for 1 point (1% of $1500).

This will keep you on the safe side, and you will be able to manage your finances efficiently.

Bottom Line

In conclusion, you should get into a detailed study of all betting concepts and methods before placing the bets. This will enhance your logical reasoning and help you in better decision-making.

Managing your bankroll and having a deep understanding of odds and betting lines are some of the tips you must follow to earn profits.

THE AFRO PEPITES SHOW

This is the run-up to the grand final. A few weeks ago, when the selection of the applications was finalised, the members of the committee drew the same conclusion. Selections are sometimes unfair ones. What criterion should prevail? Mastery or promise for a bright future? The artist’s personality, or his/her capacity to express empathy and reflect the world? The times are so difficult and emergencies so numerous that creation must stand its ground. As one jury member wrote in a post. “There’s the ‘I’, there’s the game and the us, there’s them and you. As for us… we are a little bit confused.” One hundred and fifty-eight applications! One hundred and fifty-eight words and colours, sounds, reflections and rhythms. We are a bit confused… to sort out only ten. The Afro Pepites Show is not a competition, it’s an online trade fair. We don’t play football. But you still have to make a choice.

This time, it’s done. Ten, like the fingers of the two hands that wrote the texts and placed the colours, that struck the tom-tom and spread the gesture. Ten messages, twenty fingers producing meaning, twenty ways of being, in eight African countries: Cameroon, South Africa, Ivory Coast, Zimbabwe, Madagascar, Mali, the Republic of Guinea and Burkina Faso. And once again, it’s a difficult task, given that the entire continent is multiplying the number of tracks. Ten signatures and 148 others behind them, because the Pépites are also a state of mind, a topicality, a deep need to say together, in one way or another, that this voice is ours.

So when it comes to the final selection, the decision is up to you. For you that fill the concert venues, attend exhibitions, showcases, for you stand in the arena and are part of the picture too. You who fill the halls, you who attend exhibitions and performances, you who stand at the foot of the stage and in the painting too. This is how art works. Proximity is essential. Virtuality remains an illusion. For as long as the Pepites have existed, they have had this driving force, this trust, and this will apply on 15 December, when we announce the new pepites. Your choice, your artist, your desire, your vote. It’s up to you to have your say until 30 November 2023! And as many of you as possible should take part. In less than a month, this final picture will be yours.

Attend a World of Style

Prepare to embark on a fashion journey like no other as La Peony Clothing (LPC) invites you to an exclusive event on Saturday, November 18th! Get ready to be captivated by the vision and passion of the founder, Melony Huber as she takes you behind the scenes and unveils the magic that sets LPC apart from the rest. LPC is not just another women’s fashion brand – but a movement driven by purpose, committed to celebrating skilled craftspeople and advocating for ethical fashion. Huber whose unwavering dedication fuels the brand’s essence with heart and soul poured into each and every piece. Keeping in touch with consumers is one of the brand’s missions in the digital age, and learning about products as consumers is equally crucial.

So come enjoy, experience, and meet the LPC team and take part in an evening with driven, inspirational, and like-minded women making a difference in the community and beyond:

WHEN | Saturday, November 18th, 2023
TIME | 4:30pm – 7:30pm
WHERE | The Royce – 3301 Michelson Drive, Irvine, CA, 92612
WHY | Experience a movement driven by purpose, committed to celebrating skilled craftspeople and advocating for ethical fashion.

SIPS & BITES | There will be delectable cocktails and appetizers that will be served throughout the evening, as you immerse yourself in a premium shopping experience like no other. It’s an opportunity to connect with like-minded individuals, embrace sustainable fashion, and embark on a conscious style journey.

SHOP | As our esteemed guest, you’ll receive a gift and have the opportunity to explore the collection of ethically made goods with an exclusive discount. Elevate your wardrobe with pieces that not only make a fashion statement but also make a positive impact on the world.

A Local Charity Giveback (More info will be sent via email regarding this)

Huber has carefully handpicked fabrics and textiles sourced from Oaxaca, Mexico, renowned for their rich cultural heritage and time-honored craftsmanship. From vibrant handwoven textiles to intricate embroideries, each piece in our collection tells a tale of tradition, artistry, and sustainability. The LPC team will personally guide you through the inspiration behind each design, sharing the stories of the women artisans whose skillful hands brought them to life. Gain a deeper understanding of the cultural significance woven into every stitch and feel the connection to a global community that values craftsmanship and ethical practices.
Please let us know if you have some time to hop on a call and discuss a collaboration further.We’d love to speak more of their story below: https://lapeony.com/blogs/news/creating-a-voice-for-women-artisans

LPC stands out from the crowd by seamlessly blending style, sustainability, and social responsibility. With our founder leading the way, we invite you to experience fashion that leaves a lasting impression, both on your wardrobe and in your heart. Elevating wardrobe with pieces that not only make a fashion statement but also make a positive impact on the world.

VIP MANDATORY (SPACE LIMITED) To secure your place along with interview requests please RSVP to Brittney@thejkoagency.com or Jessica@thejkoagency.com.